DegronMD - Q5JTV8(TOR1AIP1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L307V	TCGA-3C-AALI	BRCA	TCGA	PSTSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.0833
p.L323V	DO219589	BRCA	ICGC	PSTSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.25
p.S319P	ACH-000269	Brain Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	316:320	Mutation altering degron motif	0.6752
p.P327S	ACH-002446	Gastric Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.1389
p.R316C	LS-180	large intestine	COSMIC	PSTSS	DEG_SPOP_SBC_1	316:320	Mutation altering degron motif	0.8301
p.K328N	PC-3_[JPC-3]	lung	COSMIC	PSTSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.1111

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons