DegronMD - Q5JXX7(TMEM31)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I68L	TCGA-AG-A002	READ	TCGA	PTTSS	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.2222
p.S63P	TCGA-AP-A0LP	UCEC	TCGA	PTTSS	DEG_SPOP_SBC_1	60:64	Mutation altering degron motif	0.6752
p.S63P	DO43146	UCEC	ICGC	PTTSS	DEG_SPOP_SBC_1	60:64	Mutation altering degron motif	0.6752
p.E72K	TCGA-C8-A274	BRCA	TCGA	PTTSS	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.1111
p.E72K	DO5675	BRCA	ICGC	PTTSS	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.1111
p.E72D	TCGA-D6-A74Q	HNSC	TCGA	PTTSS	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.1111
p.E72D	DO52087	HNSC	ICGC	PTTSS	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.1111
p.R57H	TCGA-E6-A2P9	UCEC	TCGA	PTTSS	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.25
p.R57H	DO43714	UCEC	ICGC	PTTSS	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.25
p.R66I	TCGA-FS-A1ZN	SKCM	TCGA	PTTSS	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.2778
p.R66I	DO38165	SKCM	ICGC	PTTSS	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.2778
p.P60R	DO228295	BRCA	ICGC	PTTSS	DEG_SPOP_SBC_1	60:64	Mutation altering degron motif	0.7512
p.R57C	DO228104	EOPC	ICGC	PTTSS	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.25
p.S50Y	DO24739	LUAD	ICGC	PTTSS	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.0556
p.R58G	AN3-CA	endometrium	COSMIC	PTTSS	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons