DegronMD - Q5JY77(GPRASP1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1139N	TCGA-19-5956	GBM	TCGA	PESSS	DEG_SPOP_SBC_1	1137:1141	Mutation altering degron motif	0.7069
p.S1139N	DO13863	GBM	ICGC	PESSS	DEG_SPOP_SBC_1	1137:1141	Mutation altering degron motif	0.7069
p.R1130G	TCGA-53-7813	LUAD	TCGA	PESSS	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.1389
p.R1130G	DO24349	LUAD	ICGC	PESSS	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.1389
p.S1140L	TCGA-AA-3984	COAD	TCGA	PESSS	DEG_SPOP_SBC_1	1137:1141	Mutation altering degron motif	0.7667
p.S1140L	DO9002	COAD	ICGC	PESSS	DEG_SPOP_SBC_1	1137:1141	Mutation altering degron motif	0.7667
p.S1141Y	TCGA-AP-A0LM	UCEC	TCGA	PESSS	DEG_SPOP_SBC_1	1137:1141	Mutation altering degron motif	0.712
p.S1141Y	DO43306	UCEC	ICGC	PESSS	DEG_SPOP_SBC_1	1137:1141	Mutation altering degron motif	0.712
p.C1147Y	TCGA-BH-A0WA	BRCA	TCGA	PESSS	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.1667
p.C1147Y	DO2897	BRCA	ICGC	PESSS	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.1667
p.C1147Y	DO231159	LAML	ICGC	PESSS	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.1667
p.C1144G	TCGA-BH-A203	BRCA	TCGA	PESSS	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.25
p.C1144G	DO2156	BRCA	ICGC	PESSS	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.25
p.K1150Q	TCGA-D3-A8GR	SKCM	TCGA	PESSS	DEG_SPOP_SBC_1	1137:1141	Mutation substituting flanking lysine	0.1944
p.K1150Q	DO51247	SKCM	ICGC	PESSS	DEG_SPOP_SBC_1	1137:1141	Mutation substituting flanking lysine	0.1944
p.H1128Y	TCGA-EY-A215	UCEC	TCGA	PESSS	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.0833
p.H1128Y	DO42665	UCEC	ICGC	PESSS	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.0833
p.S1134N	TCGA-IB-7651	PAAD	TCGA	PESSS	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.25
p.S1134N	DO46657	PAAD	ICGC	PESSS	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.25
p.L1129V	TCGA-VR-A8EW	ESCA	TCGA	PESSS	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.1111
p.C1144Y	DO10324	COAD	ICGC	PESSS	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.25

Kaplan plot for GPRASP1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GPRASP1

UniProt ID: Q5JY77

Entrez ID: 9737

Protein name: G-protein coupled receptor-associated sorting protein 1 (GASP-1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for GPRASP1 in