DegronMD - Q5JYT7(KIAA1755)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S302A	TCGA-44-2657	LUAD	TCGA	AGTSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.2222
p.S302A	DO25020	LUAD	ICGC	AGTSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.2222
p.S291R	TCGA-AP-A059	UCEC	TCGA	AGTSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.25
p.S291R	DO41361	UCEC	ICGC	AGTSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.25
p.P290L	TCGA-DA-A95W	SKCM	TCGA	AGTSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.2222
p.P290L	DO219479	SKCM	ICGC	AGTSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.2222
p.P290S	DO222875	MELA	ICGC	AGTSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.2222
p.T301S	DO47012	RECA	ICGC	AGTSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.25
p.A304P	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1667
p.A304P	ACH-000916	Lung Cancer	CCLE	AGTSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1667
p.A304P	NCI-H1573	lung	COSMIC	AGTSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1667
p.E307D	SIDM01774	Pancreatic Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.0833
p.E307D	ACH-000205	Pancreatic Cancer	CCLE	AGTSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.0833
p.S297F	SIDM01750	Melanoma	GDSC	AGTSS	DEG_SPOP_SBC_1	294:298	Mutation altering degron motif	0.7982
p.S297F	ACH-000801	Skin Cancer	CCLE	AGTSS	DEG_SPOP_SBC_1	294:298	Mutation altering degron motif	0.7982

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons