DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
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SPANXN5
UniProt ID:
Q5MJ07
Entrez ID:
494197
Protein name:
Sperm protein associated with the nucleus on the X chromosome N5 (Nuclear-associated protein SPAN-Xn5) (SPANX-N5) (SPANX family member N5)
External links:
UniprotKB
HGNC
RefSeq
COSMIC
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Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
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Open in full screen with detailed sequence annotations
SPANXN5
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.E11D
TCGA-AX-A2HC
UCEC
TCGA
PTSST
DEG_SPOP_SBC_1
4:8
Mutation rewiring degron network
0.25
p.E11D
DO41572
UCEC
ICGC
PTSST
DEG_SPOP_SBC_1
4:8
Mutation rewiring degron network
0.25
p.E11K
TCGA-EE-A29M
SKCM
TCGA
PTSST
DEG_SPOP_SBC_1
4:8
Mutation rewiring degron network
0.25
p.E11K
DO37404
SKCM
ICGC
PTSST
DEG_SPOP_SBC_1
4:8
Mutation rewiring degron network
0.25
p.E2K
TCGA-ER-A19M
SKCM
TCGA
PTSST
DEG_SPOP_SBC_1
4:8
Mutation substituting flanking lysine
0.3889
p.E2K
DO37798
SKCM
ICGC
PTSST
DEG_SPOP_SBC_1
4:8
Mutation substituting flanking lysine
0.3889
p.S15G
DO900
BOCA
ICGC
PTSST
DEG_SPOP_SBC_1
4:8
Mutation rewiring degron network
0.1389
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for SPANXN5 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc