DegronMD - Q5MJ08(SPANXN4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P16H	TCGA-17-Z033	LUAD	TCGA	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.1111
p.P4Q	TCGA-38-4632	LUAD	TCGA	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7035
p.P4Q	DO23858	LUAD	ICGC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7035
p.C17S	TCGA-4P-AA8J	HNSC	TCGA	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.0833
p.C17S	DO52027	HNSC	ICGC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.0833
p.E10D	TCGA-DK-A6AW	BLCA	TCGA	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.2778
p.E10D	DO48566	BLCA	ICGC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.2778
p.E10K	TCGA-Z2-A8RT	SKCM	TCGA	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.2778
p.E10K	DO51301	SKCM	ICGC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.2778
p.S6V	DO222423	MELA	ICGC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.758
p.K12N	DO222749	MELA	ICGC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation substituting flanking lysine	0.3333
p.M13I	DO222843	MELA	ICGC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.1944
p.P4S	DO232224	PBCA	ICGC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.6752
p.S6A	DO37425	SKCM	ICGC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7588
p.S6F	DO37425	SKCM	ICGC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7982
p.T8N	SIDM00279	Gastric Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7055
p.T8N	ACH-000225	Gastric Cancer	CCLE	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7055
p.T8N	ECC12	stomach	COSMIC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7055
p.P4T	ACH-002102	Lung Cancer	CCLE	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7031
p.P4T	EMC-BAC-2	lung	COSMIC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7031

Kaplan plot for SPANXN4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPANXN4

UniProt ID: Q5MJ08

Entrez ID: 441525

Protein name: Sperm protein associated with the nucleus on the X chromosome N4 (Nuclear-associated protein SPAN-Xn4) (SPANX-N4) (SPANX family member N4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPANXN4 in