DegronMD - Q5MJ10(SPANXN2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S15I	TCGA-43-2578	LUSC	TCGA	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.1389
p.S15I	TCGA-AP-A051	UCEC	TCGA	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.1389
p.S15I	DO26662	LUSC	ICGC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.1389
p.S15I	DO42673	UCEC	ICGC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.1389
p.P4Q	TCGA-CR-7398	HNSC	TCGA	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7035
p.P4Q	DO14782	HNSC	ICGC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7035
p.E2Q	TCGA-DK-AA74	BLCA	TCGA	PTSST	DEG_SPOP_SBC_1	4:8	Mutation substituting flanking lysine	0.3889
p.E2Q	DO219011	BLCA	ICGC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation substituting flanking lysine	0.3889
p.K12N	TCGA-E5-A2PC	BLCA	TCGA	PTSST	DEG_SPOP_SBC_1	4:8	Mutation substituting flanking lysine	0.3333
p.K12N	DO702	BLCA	ICGC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation substituting flanking lysine	0.3333
p.K12N	DO44868	LICA	ICGC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation substituting flanking lysine	0.3333
p.S7I	TCGA-EO-A22U	UCEC	TCGA	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7341
p.S7I	DO43755	UCEC	ICGC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7341
p.P16H	TCGA-F5-6571	READ	TCGA	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.1111
p.P16H	DO36874	READ	ICGC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.1111
p.S7R	DO228974	LICA	ICGC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7427
p.Q3K	DO228974	LICA	ICGC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation substituting flanking lysine	0.4167
p.K12T	SIDM02070	Esophageal Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation substituting flanking lysine	0.3333
p.E11V	SIDM00570	Gastric Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.25
p.E11V	ACH-000674	Gastric Cancer	CCLE	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.25
p.T8I	SIDM01265	Plasma Cell Myeloma	GDSC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7078
p.T8I	SIDM00773	Non-Cancerous	GDSC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7078
p.T8I	SIDM00633	Breast Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7078
p.T8I	SIDM00210	Ovarian Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7078
p.T8I	SIDM00849	Kidney Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7078
p.T8I	SIDM00493	Other Solid Cancers	GDSC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7078
p.T8I	SIDM00539	Esophageal Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7078
p.T8I	SIDM00793	Burkitt's Lymphoma	GDSC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7078
p.T8I	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7078
p.T8I	SIDM00257	Neuroblastoma	GDSC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7078
p.T8I	SIDM00785	Acute Myeloid Leukemia	GDSC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7078
p.T8I	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7078
p.T8I	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7078
p.R13S	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.1944
p.R13S	ACH-000924	Lung Cancer	CCLE	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.1944
p.R13S	NCI-H2172	lung	COSMIC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPANXN2

UniProt ID: Q5MJ10

Entrez ID: 494119

Protein name: Sperm protein associated with the nucleus on the X chromosome N2 (Nuclear-associated protein SPAN-Xn2) (SPANX-N2) (SPANX family member N2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPANXN2 in