RABGAP1L
UniProt ID: Q5R372
Entrez ID: 9910
Protein name: Rab GTPase-activating protein 1-like
External links: UniprotKB HGNC RefSeq COSMIC
Please click HERE
for better display.
FUNCTION: GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (PubMed:16923123). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endo...
FUNCTION: GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (PubMed:16923123). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:A6H6A9, ECO:0000269|PubMed:16923123}.
View more >>
GO - Biological processes (BP):
activation of GTPase activity [GO:0090630]; endocytosis [GO:0006897]; protein transport [GO:0015031]; regulation of protein localization [GO:0032880]...
activation of GTPase activity [GO:0090630]; endocytosis [GO:0006897]; protein transport [GO:0015031]; regulation of protein localization [GO:0032880]
View more >>
GO - Molecular function (MF):
GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]...
GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]
View more >>
GO - Cellular component (CC):
early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]...
early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]
View more >>
RABGAP1L
Control panel
Show dataset:
Show Degron:
All sites
Degron
Degron
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for RABGAP1L in
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc