DegronMD - Q5SQS7(SH2D4B)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D421A	DO15166	HNSC	ICGC	PPDY	ITCH	423:426	Mutation rewiring degron network	0.2778
p.P424Q	DO23907	LUAD	ICGC	PPDY	ITCH	423:426	Mutation altering degron motif	0.7035
p.G418V	DO23624	LUAD	ICGC	PPDY	ITCH	423:426	Mutation rewiring degron network	0.1944
p.P424L	DO220888	MELA	ICGC	PPDY	ITCH	423:426	Mutation altering degron motif	0.7582
p.P423L	DO42608	UCEC	ICGC	PPDY	ITCH	423:426	Mutation altering degron motif	0.7582
p.C419W	LC-2-ad	lung	COSMIC	PPDY	ITCH	423:426	Mutation rewiring degron network	0.2222

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons