DegronMD - Q5SRI9(MANEA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R428S	TCGA-49-6761	LUAD	TCGA	DYR	CBL_MET	426:428	Mutation altering degron motif	0.7427
p.R428S	DO24566	LUAD	ICGC	DYR	CBL_MET	426:428	Mutation altering degron motif	0.7427
p.P429H	TCGA-A5-A0G2	UCEC	TCGA	DYR	CBL_MET	426:428	Mutation rewiring degron network	0.3056
p.P429H	DO41235	UCEC	ICGC	DYR	CBL_MET	426:428	Mutation rewiring degron network	0.3056
p.P416S	TCGA-CD-8535	STAD	TCGA	DYR	CBL_MET	426:428	Mutation rewiring degron network	0.0556
p.P416S	TCGA-D3-A8GI	SKCM	TCGA	DYR	CBL_MET	426:428	Mutation rewiring degron network	0.0556
p.P416S	DO50284	SKCM	ICGC	DYR	CBL_MET	426:428	Mutation rewiring degron network	0.0556
p.P416S	DO47741	STAD	ICGC	DYR	CBL_MET	426:428	Mutation rewiring degron network	0.0556
p.P432Q	TCGA-D3-A2JK	SKCM	TCGA	DYR	CBL_MET	426:428	Mutation rewiring degron network	0.2222
p.P432Q	TCGA-D3-A2JL	SKCM	TCGA	DYR	CBL_MET	426:428	Mutation rewiring degron network	0.2222
p.P432Q	DO37619	SKCM	ICGC	DYR	CBL_MET	426:428	Mutation rewiring degron network	0.2222
p.P432Q	DO47278	SKCM	ICGC	DYR	CBL_MET	426:428	Mutation rewiring degron network	0.2222
p.L425I	TCGA-D3-A3C6	SKCM	TCGA	DYR	CBL_MET	426:428	Mutation rewiring degron network	0.3056
p.L425I	DO37507	SKCM	ICGC	DYR	CBL_MET	426:428	Mutation rewiring degron network	0.3056
p.L434F	DO223020	ESCA	ICGC	DYR	CBL_MET	426:428	Mutation rewiring degron network	0.1667
p.S420I	DO229009	LICA	ICGC	DYR	CBL_MET	426:428	Mutation rewiring degron network	0.1667
p.K417R	DO231858	LINC	ICGC	DYR	CBL_MET	426:428	Mutation substituting flanking lysine	0.1944
p.H430Y	DO222843	MELA	ICGC	DYR	CBL_MET	426:428	Mutation rewiring degron network	0.2778
p.R428H	SIDM00499	Prostate Carcinoma	GDSC	DYR	CBL_MET	426:428	Mutation altering degron motif	0.8244
p.R428H	ACH-000956	Prostate Cancer	CCLE	DYR	CBL_MET	426:428	Mutation altering degron motif	0.8244
p.R428H	22RV1	prostate	COSMIC	DYR	CBL_MET	426:428	Mutation altering degron motif	0.8244

Kaplan plot for MANEA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MANEA

UniProt ID: Q5SRI9

Entrez ID: 79694

Protein name: Glycoprotein endo-alpha-1,2-mannosidase (Endo-alpha mannosidase) (Endomannosidase) (hEndo) (EC 3.2.1.130) (Mandaselin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MANEA in