DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
C6orf141
UniProt ID:
Q5SZD1
Entrez ID:
135398
Protein name:
Uncharacterized protein C6orf141
External links:
UniprotKB
HGNC
RefSeq
COSMIC
Please click
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for better display.
Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
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Choose a PDB ID:
Open in full screen with detailed sequence annotations
C6orf141
M
N
D
P
F
A
R
M
E
T
R
G
P
Q
G
A
A
N
P
M
D
S
S
R
S
L
G
D
L
G
P
F
P
R
E
V
G
R
G
A
P
L
A
P
G
A
R
N
P
A
T
A
G
A
S
R
S
Q
G
G
G
H
E
D
R
T
A
D
R
A
L
G
P
R
A
G
E
E
L
D
R
E
S
W
V
R
E
K
V
L
F
L
L
H
P
E
R
W
L
G
T
R
G
D
P
A
R
E
E
V
A
G
A
E
D
L
P
H
A
G
G
E
D
H
G
E
E
P
N
Y
P
S
V
F
Q
R
Q
K
R
I
S
G
R
R
V
A
P
P
R
D
A
A
D
P
P
K
Y
V
L
V
R
V
E
D
Y
Q
V
T
Q
E
V
L
Q
T
S
W
A
K
G
R
M
T
T
R
T
E
E
H
F
V
T
A
L
T
F
R
S
S
R
E
G
Q
P
G
E
R
W
G
P
A
E
S
R
A
L
Q
A
R
T
G
A
S
R
V
H
A
A
G
R
R
V
S
P
S
P
G
T
W
L
E
E
I
K
L
20
40
60
80
100
120
140
160
180
200
220
240
Residue number
0
0.5
1
1.5
2
2.5
3
3.5
4
4.5
5
5.5
Number of mutated samples
0
0.5
1
1.5
2
2.5
3
Phosphorylation sites
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Cancer
Sample
Mutation type
Dataset
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entries
Search:
Degron hit
Class
E3 ligase
Source protein
Location
Detail
PPKY
ITCH
ITCH,NEDD4
Uncharacterized protein C6orf141
154:157
More..
Showing 1 to 1 of 1 entries
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Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
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entries
Search:
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.V158L
DO34769
PACA
ICGC
PPKY
ITCH
154:157
Mutation rewiring degron network
0.3056
p.V160L
DO229026
LICA
ICGC
PPKY
ITCH
154:157
Mutation rewiring degron network
0.25
p.D164Y
DO229029
LICA
ICGC
PPKY
ITCH
154:157
Mutation rewiring degron network
0.1389
p.P147L
DO232224
PBCA
ICGC
PPKY
ITCH
154:157
Mutation rewiring degron network
0.1389
Showing 1 to 4 of 4 entries
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Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for C6orf141 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc