DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
MORN1
UniProt ID:
Q5T089
Entrez ID:
79906
Protein name:
MORN repeat-containing protein 1
External links:
UniprotKB
HGNC
RefSeq
COSMIC
Please click
HERE
for better display.
Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
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Choose a PDB ID:
Open in full screen with detailed sequence annotations
MORN1
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.L371I
TCGA-AP-A0LM
UCEC
TCGA
PPGY
ITCH
376:379
Mutation rewiring degron network
0.1944
p.L371I
DO43306
UCEC
ICGC
PPGY
ITCH
376:379
Mutation rewiring degron network
0.1944
p.P376S
TCGA-EE-A3AG
SKCM
TCGA
PPGY
ITCH
376:379
Mutation altering degron motif
0.6752
p.P376S
DO37471
SKCM
ICGC
PPGY
ITCH
376:379
Mutation altering degron motif
0.6752
p.Y379C
SIDM00958
Chronic Myelogenous Leukemia
GDSC
PPGY
ITCH
376:379
Mutation altering degron motif
0.7087
p.Y379C
ACH-000920
Leukemia
CCLE
PPGY
ITCH
376:379
Mutation altering degron motif
0.7087
p.P375S
SIDM01240
Melanoma
GDSC
PPGY
ITCH
376:379
Mutation rewiring degron network
0.3056
p.P375S
451Lu
skin
COSMIC
PPGY
ITCH
376:379
Mutation rewiring degron network
0.3056
p.H389Y
SIDM01107
Melanoma
GDSC
PPGY
ITCH
376:379
Mutation rewiring degron network
0.0556
p.H389Y
SK-MEL-1
skin
COSMIC
PPGY
ITCH
376:379
Mutation rewiring degron network
0.0556
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for MORN1 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc