DegronMD - Q5T3F8(TMEM63B)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D786N	TCGA-94-7557	LUSC	TCGA	PPSSS	DEG_SPOP_SBC_1	796:800	Mutation rewiring degron network	0.0556
p.D786N	DO26728	LUSC	ICGC	PPSSS	DEG_SPOP_SBC_1	796:800	Mutation rewiring degron network	0.0556
p.Q802K	TCGA-BF-A1PU	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	796:800	Mutation rewiring degron network	0.2778
p.Q802K	DO50278	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	796:800	Mutation rewiring degron network	0.2778
p.P789L	TCGA-EE-A29N	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	796:800	Mutation rewiring degron network	0.1389
p.P789L	DO38001	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	796:800	Mutation rewiring degron network	0.1389
p.S800P	TCGA-EO-A3AU	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	796:800	Mutation altering degron motif	0.6752
p.S800P	DO43827	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	796:800	Mutation altering degron motif	0.6752
p.G793R	DO233140	GACA	ICGC	PPSSS	DEG_SPOP_SBC_1	796:800	Mutation rewiring degron network	0.25
p.E804G	DO233175	GACA	ICGC	PPSSS	DEG_SPOP_SBC_1	796:800	Mutation rewiring degron network	0.2222
p.S799P	DO23488	LINC	ICGC	PPSSS	DEG_SPOP_SBC_1	796:800	Mutation altering degron motif	0.6752

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons