DegronMD - Q5VUA4(ZNF318)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1335S	TCGA-26-1799	GBM	TCGA	VVTTS	DEG_SPOP_SBC_1	1339:1343	Mutation rewiring degron network	0.2222
p.P1335S	DO11603	GBM	ICGC	VVTTS	DEG_SPOP_SBC_1	1339:1343	Mutation rewiring degron network	0.2222
p.P1353S	TCGA-2W-A8YY	CESC	TCGA	VVTTS	DEG_SPOP_SBC_1	1339:1343	Mutation rewiring degron network	0.0556
p.P1353S	DO223732	CESC	ICGC	VVTTS	DEG_SPOP_SBC_1	1339:1343	Mutation rewiring degron network	0.0556
p.P1268A	TCGA-3A-A9I7	PAAD	TCGA	PTSSS	DEG_SPOP_SBC_1	1268:1272	Mutation altering degron motif	0.6392
p.P1268A	DO51678	PAAD	ICGC	PTSSS	DEG_SPOP_SBC_1	1268:1272	Mutation altering degron motif	0.6392
p.K847N	TCGA-63-A5MB	LUSC	TCGA	SRPNLRVIP	DEG_APCC_DBOX_1	831:839	Mutation substituting flanking lysine	0.2222
p.K847N	DO52018	LUSC	ICGC	SRPNLRVIP	DEG_APCC_DBOX_1	831:839	Mutation substituting flanking lysine	0.2222
p.S1270L	TCGA-90-7964	LUSC	TCGA	PTSSS	DEG_SPOP_SBC_1	1268:1272	Mutation altering degron motif	0.7667
p.S1270L	DO27046	LUSC	ICGC	PTSSS	DEG_SPOP_SBC_1	1268:1272	Mutation altering degron motif	0.7667
p.P784T	TCGA-A5-A0G2	UCEC	TCGA	PPNY	ITCH	775:778	Mutation rewiring degron network	0.1667
p.P784T	DO41235	UCEC	ICGC	PPNY	ITCH	775:778	Mutation rewiring degron network	0.1667
p.D221H	TCGA-A7-A6VX	BRCA	TCGA	DYR	CBL_MET	223:225	Mutation rewiring degron network	0.2778
p.D221H	DO50019	BRCA	ICGC	DYR	CBL_MET	223:225	Mutation rewiring degron network	0.2778
p.T1342A	TCGA-AA-3815	COAD	TCGA	VVTTS	DEG_SPOP_SBC_1	1339:1343	Mutation altering degron motif	0.7139
p.T1342A	DO9924	COAD	ICGC	VVTTS	DEG_SPOP_SBC_1	1339:1343	Mutation altering degron motif	0.7139
p.S1270A	TCGA-AJ-A3EK	UCEC	TCGA	PTSSS	DEG_SPOP_SBC_1	1268:1272	Mutation altering degron motif	0.7588
p.S1270A	DO41584	UCEC	ICGC	PTSSS	DEG_SPOP_SBC_1	1268:1272	Mutation altering degron motif	0.7588
p.E1266K	TCGA-AP-A059	UCEC	TCGA	PTSSS	DEG_SPOP_SBC_1	1268:1272	Mutation rewiring degron network	0.2778
p.E1266K	DO41361	UCEC	ICGC	PTSSS	DEG_SPOP_SBC_1	1268:1272	Mutation rewiring degron network	0.2778
p.L412I	TCGA-AX-A3FT	UCEC	TCGA	DHPLYSGHP	CBL_PTK	409:417	Mutation altering degron motif	0.6063
p.L412I	DO40801	UCEC	ICGC	DHPLYSGHP	CBL_PTK	409:417	Mutation altering degron motif	0.6063
p.R526C	TCGA-B7-5816	STAD	TCGA	ADSTS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.1389
p.R526C	DO38599	STAD	ICGC	ADSTS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.1389
p.R526C	SIDM00698	Small Cell Lung Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.1389
p.R526C	SIDM01228	Melanoma	GDSC	ADSTS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.1389
p.E1302Q	TCGA-C5-A2LY	CESC	TCGA	LVTPSIS	DEG_SCF_FBW7_1	1290:1296	Mutation rewiring degron network	0.1667
p.E1302Q	DO6314	CESC	ICGC	LVTPSIS	DEG_SCF_FBW7_1	1290:1296	Mutation rewiring degron network	0.1667
p.S517F	TCGA-C8-A8HP	BRCA	TCGA	ADSTS	DEG_SPOP_SBC_1	515:519	Mutation altering degron motif	0.7982
p.S517F	DO219621	BRCA	ICGC	ADSTS	DEG_SPOP_SBC_1	515:519	Mutation altering degron motif	0.7982
p.R830C	TCGA-CD-8527	STAD	TCGA	SRPNLRVIP	DEG_APCC_DBOX_1	831:839	Mutation rewiring degron network	0.3056
p.R830C	DO47739	STAD	ICGC	SRPNLRVIP	DEG_APCC_DBOX_1	831:839	Mutation rewiring degron network	0.3056
p.A771T	TCGA-CD-A4MG	STAD	TCGA	PPNY	ITCH	775:778	Mutation rewiring degron network	0.2222
p.A771T	DO48009	STAD	ICGC	PPNY	ITCH	775:778	Mutation rewiring degron network	0.2222
p.P529S	TCGA-CQ-5331	HNSC	TCGA	ADSTS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.0556
p.P529S	DO15495	HNSC	ICGC	ADSTS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.0556
p.D235N	TCGA-CV-5978	HNSC	TCGA	DYR	CBL_MET	223:225	Mutation rewiring degron network	0.0556
p.D235N	DO16023	HNSC	ICGC	DYR	CBL_MET	223:225	Mutation rewiring degron network	0.0556
p.E817Q	TCGA-DR-A0ZM	CESC	TCGA	TSQPSNHPVPEP	DEG_COP1_1	807:818	Mutation altering degron motif	0.6744
p.E817Q	DO6254	CESC	ICGC	TSQPSNHPVPEP	DEG_COP1_1	807:818	Mutation altering degron motif	0.6744
p.Q848H	TCGA-E2-A1LA	BRCA	TCGA	SRPNLRVIP	DEG_APCC_DBOX_1	831:839	Mutation rewiring degron network	0.0833
p.Q848H	DO3164	BRCA	ICGC	SRPNLRVIP	DEG_APCC_DBOX_1	831:839	Mutation rewiring degron network	0.0833
p.P784S	TCGA-EB-A41A	SKCM	TCGA	PPNY	ITCH	775:778	Mutation rewiring degron network	0.1667
p.P784S	DO37429	SKCM	ICGC	PPNY	ITCH	775:778	Mutation rewiring degron network	0.1667
p.P215S	TCGA-EE-A2GB	SKCM	TCGA	DYR	CBL_MET	223:225	Mutation rewiring degron network	0.1111
p.P215S	DO222683	MELA	ICGC	DYR	CBL_MET	223:225	Mutation rewiring degron network	0.1111
p.P215S	DO37417	SKCM	ICGC	DYR	CBL_MET	223:225	Mutation rewiring degron network	0.1111
p.P215L	TCGA-EE-A2MR	SKCM	TCGA	DYR	CBL_MET	223:225	Mutation rewiring degron network	0.1111
p.P215L	DO37819	SKCM	ICGC	DYR	CBL_MET	223:225	Mutation rewiring degron network	0.1111
p.K1280N	TCGA-EO-A22R	UCEC	TCGA	LVTPSIS	DEG_SCF_FBW7_1	1290:1296	Mutation substituting flanking lysine	0.1667
p.K1280N	TCGA-EO-A22R	UCEC	TCGA	PTSSS	DEG_SPOP_SBC_1	1268:1272	Mutation substituting flanking lysine	0.2222
p.K1280N	DO42713	UCEC	ICGC	LVTPSIS	DEG_SCF_FBW7_1	1290:1296	Mutation substituting flanking lysine	0.1667
p.K1280N	DO42713	UCEC	ICGC	PTSSS	DEG_SPOP_SBC_1	1268:1272	Mutation substituting flanking lysine	0.2222
p.E1299D	TCGA-F5-6814	READ	TCGA	LVTPSIS	DEG_SCF_FBW7_1	1290:1296	Mutation rewiring degron network	0.25
p.E1299D	DO36556	READ	ICGC	LVTPSIS	DEG_SCF_FBW7_1	1290:1296	Mutation rewiring degron network	0.25
p.P810Q	TCGA-FS-A1ZB	SKCM	TCGA	TSQPSNHPVPEP	DEG_COP1_1	807:818	Mutation altering degron motif	0.5924
p.P810Q	DO37886	SKCM	ICGC	TSQPSNHPVPEP	DEG_COP1_1	807:818	Mutation altering degron motif	0.5924
p.R836C	TCGA-FW-A3R5	SKCM	TCGA	SRPNLRVIP	DEG_APCC_DBOX_1	831:839	Mutation altering degron motif	0.719
p.R836C	DO37406	SKCM	ICGC	SRPNLRVIP	DEG_APCC_DBOX_1	831:839	Mutation altering degron motif	0.719
p.S1296C	TCGA-G2-AA3C	BLCA	TCGA	LVTPSIS	DEG_SCF_FBW7_1	1290:1296	Mutation altering degron motif	0.8652
p.S1296C	DO51883	BLCA	ICGC	LVTPSIS	DEG_SCF_FBW7_1	1290:1296	Mutation altering degron motif	0.8652
p.R509C	TCGA-G3-A25Z	LIHC	TCGA	ADSTS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.1667
p.R509C	DO23078	LIHC	ICGC	ADSTS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.1667
p.R509C	DO27961	ORCA	ICGC	ADSTS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.1667
p.R509C	SIDM00761	Small Cell Lung Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.1667
p.R509C	ACH-000752	Lung Cancer	CCLE	ADSTS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.1667
p.R509C	NCI-H196	lung	COSMIC	ADSTS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.1667
p.Q408H	TCGA-G7-6797	KIRP	TCGA	DHPLYSGHP	CBL_PTK	409:417	Mutation rewiring degron network	0.3056
p.Q408H	DO20917	KIRP	ICGC	DHPLYSGHP	CBL_PTK	409:417	Mutation rewiring degron network	0.3056
p.P1335H	TCGA-IB-7651	PAAD	TCGA	VVTTS	DEG_SPOP_SBC_1	1339:1343	Mutation rewiring degron network	0.2222
p.P1335H	DO46657	PAAD	ICGC	VVTTS	DEG_SPOP_SBC_1	1339:1343	Mutation rewiring degron network	0.2222
p.Q809E	TCGA-IR-A3LA	CESC	TCGA	TSQPSNHPVPEP	DEG_COP1_1	807:818	Mutation altering degron motif	0.5633
p.Q809E	DO44377	CESC	ICGC	TSQPSNHPVPEP	DEG_COP1_1	807:818	Mutation altering degron motif	0.5633
p.V837M	TCGA-QG-A5Z2	COAD	TCGA	SRPNLRVIP	DEG_APCC_DBOX_1	831:839	Mutation altering degron motif	0.6097
p.V837M	DO44096	COAD	ICGC	SRPNLRVIP	DEG_APCC_DBOX_1	831:839	Mutation altering degron motif	0.6097
p.T1292I	DO227999	COCA	ICGC	LVTPSIS	DEG_SCF_FBW7_1	1290:1296	Mutation altering degron motif	0.7078
p.T1292I	DO229016	COCA	ICGC	LVTPSIS	DEG_SCF_FBW7_1	1290:1296	Mutation altering degron motif	0.7078
p.T1292I	DO218838	SKCA	ICGC	LVTPSIS	DEG_SCF_FBW7_1	1290:1296	Mutation altering degron motif	0.7078
p.P1335R	DO222754	ESCA	ICGC	VVTTS	DEG_SPOP_SBC_1	1339:1343	Mutation rewiring degron network	0.2222
p.L511M	DO229019	LICA	ICGC	ADSTS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.2222
p.N777K	DO229015	LICA	ICGC	PPNY	ITCH	775:778	Mutation altering degron motif	0.5806
p.P823T	DO229022	LICA	ICGC	SRPNLRVIP	DEG_APCC_DBOX_1	831:839	Mutation rewiring degron network	0.1111
p.P823T	DO229022	LICA	ICGC	TSQPSNHPVPEP	DEG_COP1_1	807:818	Mutation rewiring degron network	0.1944
p.P823T	DO229038	LICA	ICGC	SRPNLRVIP	DEG_APCC_DBOX_1	831:839	Mutation rewiring degron network	0.1111
p.P823T	DO229038	LICA	ICGC	TSQPSNHPVPEP	DEG_COP1_1	807:818	Mutation rewiring degron network	0.1944
p.T842N	DO229026	LICA	ICGC	SRPNLRVIP	DEG_APCC_DBOX_1	831:839	Mutation blocking phosphorylation signal	0.6944
p.A828D	DO229026	LICA	ICGC	SRPNLRVIP	DEG_APCC_DBOX_1	831:839	Mutation rewiring degron network	0.25
p.A828D	DO229026	LICA	ICGC	TSQPSNHPVPEP	DEG_COP1_1	807:818	Mutation rewiring degron network	0.0556
p.S512R	DO229032	LICA	ICGC	ADSTS	DEG_SPOP_SBC_1	515:519	Mutation blocking phosphorylation signal	0.6944
p.R832S	DO229008	LICA	ICGC	SRPNLRVIP	DEG_APCC_DBOX_1	831:839	Mutation altering degron motif	0.7427
p.E1261Q	DO221545	PACA	ICGC	PTSSS	DEG_SPOP_SBC_1	1268:1272	Mutation rewiring degron network	0.1389
p.S512N	DO232761	PBCA	ICGC	ADSTS	DEG_SPOP_SBC_1	515:519	Mutation blocking phosphorylation signal	0.6944
p.S1334R	DO232224	PBCA	ICGC	VVTTS	DEG_SPOP_SBC_1	1339:1343	Mutation rewiring degron network	0.1944
p.T825I	DO219878	SKCA	ICGC	SRPNLRVIP	DEG_APCC_DBOX_1	831:839	Mutation blocking phosphorylation signal	0.6111
p.T825I	DO219878	SKCA	ICGC	TSQPSNHPVPEP	DEG_COP1_1	807:818	Mutation blocking phosphorylation signal	0.5833
p.E1302K	DO229459	SKCA	ICGC	LVTPSIS	DEG_SCF_FBW7_1	1290:1296	Mutation rewiring degron network	0.1667
p.P1293R	SIDM00422	Hodgkin's Lymphoma	GDSC	LVTPSIS	DEG_SCF_FBW7_1	1290:1296	Mutation altering degron motif	0.7512
p.P1293R	ACH-001203	Lymphoma	CCLE	LVTPSIS	DEG_SCF_FBW7_1	1290:1296	Mutation altering degron motif	0.7512
p.P1293R	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	LVTPSIS	DEG_SCF_FBW7_1	1290:1296	Mutation altering degron motif	0.7512
p.A828T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	SRPNLRVIP	DEG_APCC_DBOX_1	831:839	Mutation rewiring degron network	0.25
p.A828T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	TSQPSNHPVPEP	DEG_COP1_1	807:818	Mutation rewiring degron network	0.0556
p.A828T	ACH-000981	Leukemia	CCLE	SRPNLRVIP	DEG_APCC_DBOX_1	831:839	Mutation rewiring degron network	0.25
p.A828T	ACH-000981	Leukemia	CCLE	TSQPSNHPVPEP	DEG_COP1_1	807:818	Mutation rewiring degron network	0.0556
p.A828T	DND-41	haematopoietic and lymphoid tissue	COSMIC	SRPNLRVIP	DEG_APCC_DBOX_1	831:839	Mutation rewiring degron network	0.25
p.A828T	DND-41	haematopoietic and lymphoid tissue	COSMIC	TSQPSNHPVPEP	DEG_COP1_1	807:818	Mutation rewiring degron network	0.0556
p.G1274R	SIDM00884	Breast Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	1268:1272	Mutation rewiring degron network	0.2778
p.G1274R	ACH-000699	Breast Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	1268:1272	Mutation rewiring degron network	0.2778
p.G1274R	HCC1395	breast	COSMIC	PTSSS	DEG_SPOP_SBC_1	1268:1272	Mutation rewiring degron network	0.2778
p.A770V	SIDM00499	Prostate Carcinoma	GDSC	PPNY	ITCH	775:778	Mutation rewiring degron network	0.1944
p.A770V	ACH-000956	Prostate Cancer	CCLE	PPNY	ITCH	775:778	Mutation rewiring degron network	0.1944
p.A770V	22RV1	prostate	COSMIC	PPNY	ITCH	775:778	Mutation rewiring degron network	0.1944
p.R509L	SIDM00399	Head and Neck Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.1667
p.R509L	SCC90	upper aerodigestive tract	COSMIC	ADSTS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.1667
p.K227R	SIDM00845	Burkitt's Lymphoma	GDSC	DYR	CBL_MET	223:225	Mutation rewiring degron network	0.2778
p.S234F	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	DYR	CBL_MET	223:225	Mutation blocking phosphorylation signal	0.5278
p.S234F	ACH-000809	Esophageal Cancer	CCLE	DYR	CBL_MET	223:225	Mutation blocking phosphorylation signal	0.5278
p.S234F	KYSE-410	oesophagus	COSMIC	DYR	CBL_MET	223:225	Mutation blocking phosphorylation signal	0.5278
p.F230S	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	DYR	CBL_MET	223:225	Mutation rewiring degron network	0.1944
p.F230S	ACH-000563	Lung Cancer	CCLE	DYR	CBL_MET	223:225	Mutation rewiring degron network	0.1944
p.F230S	EBC-1	lung	COSMIC	DYR	CBL_MET	223:225	Mutation rewiring degron network	0.1944
p.K826R	SIDM00272	Breast Carcinoma	GDSC	SRPNLRVIP	DEG_APCC_DBOX_1	831:839	Mutation substituting flanking lysine	0.3056
p.K826R	SIDM00272	Breast Carcinoma	GDSC	TSQPSNHPVPEP	DEG_COP1_1	807:818	Mutation substituting flanking lysine	0.2222
p.K826R	ACH-000910	Breast Cancer	CCLE	SRPNLRVIP	DEG_APCC_DBOX_1	831:839	Mutation substituting flanking lysine	0.3056
p.K826R	ACH-000910	Breast Cancer	CCLE	TSQPSNHPVPEP	DEG_COP1_1	807:818	Mutation substituting flanking lysine	0.2222
p.K826R	MDA-MB-453	breast	COSMIC	SRPNLRVIP	DEG_APCC_DBOX_1	831:839	Mutation substituting flanking lysine	0.3056
p.K826R	MDA-MB-453	breast	COSMIC	TSQPSNHPVPEP	DEG_COP1_1	807:818	Mutation substituting flanking lysine	0.2222
p.N812S	SIDM01133	Other Solid Cancers	GDSC	TSQPSNHPVPEP	DEG_COP1_1	807:818	Mutation altering degron motif	0.5958
p.N812S	ACH-000635	Ovarian Cancer	CCLE	TSQPSNHPVPEP	DEG_COP1_1	807:818	Mutation altering degron motif	0.5958
p.N812S	ACH-002177	Lung Cancer	CCLE	TSQPSNHPVPEP	DEG_COP1_1	807:818	Mutation altering degron motif	0.5958
p.N812S	NCI-H835	lung	COSMIC	TSQPSNHPVPEP	DEG_COP1_1	807:818	Mutation altering degron motif	0.5958
p.E1285Q	SIDM01042	Breast Carcinoma	GDSC	LVTPSIS	DEG_SCF_FBW7_1	1290:1296	Mutation rewiring degron network	0.1944
p.E1285Q	ACH-001065	Breast Cancer	CCLE	LVTPSIS	DEG_SCF_FBW7_1	1290:1296	Mutation rewiring degron network	0.1944
p.E1285Q	EVSA-T	breast	COSMIC	LVTPSIS	DEG_SCF_FBW7_1	1290:1296	Mutation rewiring degron network	0.1944
p.P776L	SIDM01013	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPNY	ITCH	775:778	Mutation altering degron motif	0.7582
p.L1301I	SIDM01588	Endometrial Carcinoma	GDSC	LVTPSIS	DEG_SCF_FBW7_1	1290:1296	Mutation rewiring degron network	0.1944
p.L1301I	ACH-000993	Endometrial/Uterine Cancer	CCLE	LVTPSIS	DEG_SCF_FBW7_1	1290:1296	Mutation rewiring degron network	0.1944
p.P785L	ACH-001210	Rhabdoid	CCLE	PPNY	ITCH	775:778	Mutation rewiring degron network	0.1389
p.S1272F	ACH-001415	Bladder Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	1268:1272	Mutation altering degron motif	0.7982
p.I838V	ACH-002287	Colon/Colorectal Cancer	CCLE	SRPNLRVIP	DEG_APCC_DBOX_1	831:839	Mutation altering degron motif	0.5965
p.I838V	NCI-H630	large intestine	COSMIC	SRPNLRVIP	DEG_APCC_DBOX_1	831:839	Mutation altering degron motif	0.5965

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF318

UniProt ID: Q5VUA4

Entrez ID: 24149

Protein name: Zinc finger protein 318 (Endocrine regulatory protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF318 in