DegronMD - Q5VUA4(ZNF318)

FUNCTION: [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.

GO - Biological processes (BP): meiotic cell cycle [GO:0051321]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]

GO - Molecular function (MF): nucleic acid binding [GO:0003676]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]

GO - Cellular component (CC): cytosol [GO:0005829]; nucleoplasm [GO:0005654]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1296C	TCGA-G2-AA3C	BLCA	TCGA	LVTPSIS	DEG_SCF_FBW7_1	1290:1296	Mutation altering degron motif	0.8652
p.S1296C	DO51883	BLCA	ICGC	LVTPSIS	DEG_SCF_FBW7_1	1290:1296	Mutation altering degron motif	0.8652
p.S517F	TCGA-C8-A8HP	BRCA	TCGA	ADSTS	DEG_SPOP_SBC_1	515:519	Mutation altering degron motif	0.7982
p.S517F	DO219621	BRCA	ICGC	ADSTS	DEG_SPOP_SBC_1	515:519	Mutation altering degron motif	0.7982
p.S1272F	ACH-001415	Bladder Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	1268:1272	Mutation altering degron motif	0.7982
p.S1270L	TCGA-90-7964	LUSC	TCGA	PTSSS	DEG_SPOP_SBC_1	1268:1272	Mutation altering degron motif	0.7667
p.S1270L	DO27046	LUSC	ICGC	PTSSS	DEG_SPOP_SBC_1	1268:1272	Mutation altering degron motif	0.7667
p.S1270A	TCGA-AJ-A3EK	UCEC	TCGA	PTSSS	DEG_SPOP_SBC_1	1268:1272	Mutation altering degron motif	0.7588
p.S1270A	DO41584	UCEC	ICGC	PTSSS	DEG_SPOP_SBC_1	1268:1272	Mutation altering degron motif	0.7588
p.P776L	SIDM01013	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPNY	ITCH	775:778	Mutation altering degron motif	0.7582
p.P1293R	SIDM00422	Hodgkin's Lymphoma	GDSC	LVTPSIS	DEG_SCF_FBW7_1	1290:1296	Mutation altering degron motif	0.7512
p.P1293R	ACH-001203	Lymphoma	CCLE	LVTPSIS	DEG_SCF_FBW7_1	1290:1296	Mutation altering degron motif	0.7512
p.P1293R	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	LVTPSIS	DEG_SCF_FBW7_1	1290:1296	Mutation altering degron motif	0.7512
p.R832S	DO229008	LICA	ICGC	SRPNLRVIP	DEG_APCC_DBOX_1	831:839	Mutation altering degron motif	0.7427
p.R836C	TCGA-FW-A3R5	SKCM	TCGA	SRPNLRVIP	DEG_APCC_DBOX_1	831:839	Mutation altering degron motif	0.719
p.R836C	DO37406	SKCM	ICGC	SRPNLRVIP	DEG_APCC_DBOX_1	831:839	Mutation altering degron motif	0.719
p.T1342A	TCGA-AA-3815	COAD	TCGA	VVTTS	DEG_SPOP_SBC_1	1339:1343	Mutation altering degron motif	0.7139
p.T1342A	DO9924	COAD	ICGC	VVTTS	DEG_SPOP_SBC_1	1339:1343	Mutation altering degron motif	0.7139
p.T1292I	DO227999	COCA	ICGC	LVTPSIS	DEG_SCF_FBW7_1	1290:1296	Mutation altering degron motif	0.7078
p.T1292I	DO229016	COCA	ICGC	LVTPSIS	DEG_SCF_FBW7_1	1290:1296	Mutation altering degron motif	0.7078

Showing 1 to 20 of 140 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF318

UniProt ID: Q5VUA4

Entrez ID: 24149

Protein name: Zinc finger protein 318 (Endocrine regulatory protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF318 in