DegronMD - Q5VW00(DCAF12L2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G19V	TCGA-49-AARQ	LUAD	TCGA	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.3056
p.G19V	DO51189	LUAD	ICGC	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.3056
p.A15S	TCGA-50-5931	LUAD	TCGA	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1944
p.A15S	DO24980	LUAD	ICGC	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1944
p.E17K	TCGA-AA-A010	COAD	TCGA	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.25
p.A20V	TCGA-AA-A01R	COAD	TCGA	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation altering degron motif	0.5825
p.A20V	DO7934	COAD	ICGC	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation altering degron motif	0.5825
p.A15T	TCGA-AJ-A3EL	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1944
p.A15T	DO41542	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1944
p.R11W	TCGA-AX-A2HD	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.0833
p.R11W	DO42608	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.0833
p.K12N	TCGA-BR-6452	STAD	TCGA	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation substituting flanking lysine	0.2222
p.K12N	DO38404	STAD	ICGC	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation substituting flanking lysine	0.2222
p.G19E	TCGA-C5-A1MH	CESC	TCGA	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.3056
p.G19E	DO48982	CESC	ICGC	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.3056
p.S24L	TCGA-CD-5800	STAD	TCGA	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation altering degron motif	0.7667
p.S24L	DO38431	STAD	ICGC	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation altering degron motif	0.7667
p.G33R	TCGA-CK-5913	COAD	TCGA	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.0833
p.G33R	DO8826	COAD	ICGC	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.0833
p.A30V	TCGA-DD-AACI	LIHC	TCGA	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1667
p.A30V	DO52205	LIHC	ICGC	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1667
p.A31G	TCGA-EB-A44Q	SKCM	TCGA	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1389
p.A31G	DO38087	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1389
p.S25L	TCGA-FS-A1ZZ	SKCM	TCGA	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation blocking phosphorylation signal	0.75
p.S25L	DO37412	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation blocking phosphorylation signal	0.75
p.A31V	TCGA-HU-A4H2	STAD	TCGA	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1389
p.A31V	TCGA-TM-A84H	LGG	TCGA	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1389
p.A31V	DO50233	LGG	ICGC	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1389
p.A31V	DO47825	STAD	ICGC	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1389
p.P14H	TCGA-MP-A5C7	LUAD	TCGA	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1667
p.P14H	DO45337	LUAD	ICGC	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1667
p.S24T	TCGA-NH-A5IV	COAD	TCGA	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation altering degron motif	0.6005
p.S24T	DO49095	COAD	ICGC	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation altering degron motif	0.6005
p.A13V	DO233103	GACA	ICGC	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1389
p.A15P	DO27120	LUSC	ICGC	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1944
p.A18V	DO42673	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.2778
p.G19R	SIDM00806	Osteosarcoma	GDSC	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.3056
p.G19R	HOS	bone	COSMIC	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.3056
p.A15E	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1944
p.A15E	ACH-000852	Lung Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1944
p.A15E	NCI-H1435	lung	COSMIC	AGSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DCAF12L2

UniProt ID: Q5VW00

Entrez ID: 340578

Protein name: DDB1- and CUL4-associated factor 12-like protein 2 (WD repeat-containing protein 40C)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DCAF12L2 in