DegronMD - Q5VWG9(TAF3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K744N	TCGA-44-A4SS	LUAD	TCGA	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation substituting flanking lysine	0.2222
p.K744N	DO24227	LUAD	ICGC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation substituting flanking lysine	0.2222
p.A751T	TCGA-5U-AB0D	THYM	TCGA	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751T	ACH-001786	Colon/Colorectal Cancer	CCLE	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.V335L	TCGA-91-8499	LUAD	TCGA	PETPNRT	DEG_SCF_FBW7_1	337:343	Mutation rewiring degron network	0.2778
p.V335L	DO45349	LUAD	ICGC	PETPNRT	DEG_SCF_FBW7_1	337:343	Mutation rewiring degron network	0.2778
p.V207F	TCGA-A3-3383	KIRC	TCGA	AREPLSSIN	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.1944
p.A751D	TCGA-AP-A1DV	UCEC	TCGA	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751D	DO43186	UCEC	ICGC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.H329R	TCGA-AX-A0J1	UCEC	TCGA	PETPNRT	DEG_SCF_FBW7_1	337:343	Mutation rewiring degron network	0.1111
p.H329R	DO41199	UCEC	ICGC	PETPNRT	DEG_SCF_FBW7_1	337:343	Mutation rewiring degron network	0.1111
p.S229Y	TCGA-AX-A2HC	UCEC	TCGA	AREPLSSIN	DEG_APCC_DBOX_1	212:220	Mutation blocking phosphorylation signal	0.5278
p.S229Y	DO41572	UCEC	ICGC	AREPLSSIN	DEG_APCC_DBOX_1	212:220	Mutation blocking phosphorylation signal	0.5278
p.D203N	TCGA-BR-A4QL	STAD	TCGA	AREPLSSIN	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.0833
p.D203N	DO38723	STAD	ICGC	AREPLSSIN	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.0833
p.R213Q	TCGA-BS-A0UV	UCEC	TCGA	AREPLSSIN	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.7329
p.R213Q	DO42793	UCEC	ICGC	AREPLSSIN	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.7329
p.D206N	TCGA-CR-7370	HNSC	TCGA	AREPLSSIN	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.1667
p.D206N	DO14426	HNSC	ICGC	AREPLSSIN	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.1667
p.A212V	TCGA-DA-A95Z	SKCM	TCGA	AREPLSSIN	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.5825
p.A212V	DO219481	SKCM	ICGC	AREPLSSIN	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.5825
p.T339M	TCGA-DM-A1HB	COAD	TCGA	PETPNRT	DEG_SCF_FBW7_1	337:343	Mutation altering degron motif	0.8534
p.L228R	TCGA-NK-A5CR	LUSC	TCGA	AREPLSSIN	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.1111
p.L228R	DO219207	LUSC	ICGC	AREPLSSIN	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.1111
p.P756L	TCGA-WE-A8K4	SKCM	TCGA	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation altering degron motif	0.6471
p.P756L	DO51281	SKCM	ICGC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation altering degron motif	0.6471
p.E350K	TCGA-XF-A9SY	BLCA	TCGA	PETPNRT	DEG_SCF_FBW7_1	337:343	Mutation rewiring degron network	0.1389
p.E350K	DO51918	BLCA	ICGC	PETPNRT	DEG_SCF_FBW7_1	337:343	Mutation rewiring degron network	0.1389
p.Q769K	TCGA-XP-A8T8	ESCA	TCGA	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.2222
p.A751V	DO229003	COCA	ICGC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751V	DO230659	LAML	ICGC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751V	DO231140	LAML	ICGC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751V	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751V	SIDM00958	Chronic Myelogenous Leukemia	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751V	SIDM00232	Kidney Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751V	SIDM00781	Colorectal Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751V	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751V	SIDM00590	Oral Cavity Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751V	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751V	SIDM01154	T-Lymphoblastic Leukemia	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751V	SIDM00040	Gastric Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751V	SIDM00282	Colorectal Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751V	SIDM00556	Neuroblastoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751V	SIDM01172	Acute Myeloid Leukemia	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751V	SIDM00587	Biliary Tract Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751V	SIDM00487	Colorectal Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751V	SIDM00251	Gastric Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751V	SIDM01210	Glioblastoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751V	SIDM00368	Small Cell Lung Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751V	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751V	SIDM00289	B-Lymphoblastic Leukemia	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751V	SIDM00316	Glioblastoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751V	SIDM01612	Endometrial Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751V	SIDM01320	Pancreatic Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751V	SIDM01611	Endometrial Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751V	SIDM01776	Plasma Cell Myeloma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751V	SIDM01471	Chronic Myelogenous Leukemia	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751V	SIDM00780	Colorectal Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751V	SIDM01413	Oral Cavity Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.S349T	DO234285	ESAD	ICGC	PETPNRT	DEG_SCF_FBW7_1	337:343	Mutation blocking phosphorylation signal	0.6111
p.Q222P	DO228750	GACA	ICGC	AREPLSSIN	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.2778
p.G766V	DO229031	LICA	ICGC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751S	DO229036	LICA	ICGC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.L205I	DO44810	LICA	ICGC	AREPLSSIN	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.1389
p.V757D	DO228338	MALY	ICGC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation altering degron motif	0.6674
p.V757D	SIDM00948	Burkitt's Lymphoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation altering degron motif	0.6674
p.V757D	ACH-002232	Lymphoma	CCLE	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation altering degron motif	0.6674
p.V757D	DG-75	haematopoietic and lymphoid tissue	COSMIC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation altering degron motif	0.6674
p.P331L	DO220857	MELA	ICGC	PETPNRT	DEG_SCF_FBW7_1	337:343	Mutation rewiring degron network	0.1667
p.D203Y	DO51479	PACA	ICGC	AREPLSSIN	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.0833
p.I330F	SIDM01099	Neuroblastoma	GDSC	PETPNRT	DEG_SCF_FBW7_1	337:343	Mutation rewiring degron network	0.1389
p.I330F	SIDM00878	Breast Carcinoma	GDSC	PETPNRT	DEG_SCF_FBW7_1	337:343	Mutation rewiring degron network	0.1389
p.I330F	SIDM00971	Breast Carcinoma	GDSC	PETPNRT	DEG_SCF_FBW7_1	337:343	Mutation rewiring degron network	0.1389
p.I330F	SIDM00032	Bladder Carcinoma	GDSC	PETPNRT	DEG_SCF_FBW7_1	337:343	Mutation rewiring degron network	0.1389
p.I330F	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	PETPNRT	DEG_SCF_FBW7_1	337:343	Mutation rewiring degron network	0.1389
p.I330F	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PETPNRT	DEG_SCF_FBW7_1	337:343	Mutation rewiring degron network	0.1389
p.I330F	SIDM00257	Neuroblastoma	GDSC	PETPNRT	DEG_SCF_FBW7_1	337:343	Mutation rewiring degron network	0.1389
p.T327M	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PETPNRT	DEG_SCF_FBW7_1	337:343	Mutation rewiring degron network	0.0556
p.T327M	ACH-000937	Leukemia	CCLE	PETPNRT	DEG_SCF_FBW7_1	337:343	Mutation rewiring degron network	0.0556
p.T327M	PF-382	haematopoietic and lymphoid tissue	COSMIC	PETPNRT	DEG_SCF_FBW7_1	337:343	Mutation rewiring degron network	0.0556
p.T221A	SIDM01608	Endometrial Carcinoma	GDSC	AREPLSSIN	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.3056
p.T221A	ACH-000990	Endometrial/Uterine Cancer	CCLE	AREPLSSIN	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.3056
p.P749L	SIDM01779	Gastric Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.25
p.P749L	ACH-000761	Gastric Cancer	CCLE	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.25
p.L348V	ACH-001303	Neuroblastoma	CCLE	PETPNRT	DEG_SCF_FBW7_1	337:343	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TAF3

UniProt ID: Q5VWG9

Entrez ID: 83860

Protein name: Transcription initiation factor TFIID subunit 3 (140 kDa TATA box-binding protein-associated factor) (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (TAF(II)140) (TAF140) (TAFII-140) (TAFII140)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TAF3 in