DegronMD - Q5VWG9(TAF3)

FUNCTION: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly ... View more >>

GO - Biological processes (BP): maintenance of protein location in nucleus [GO:0051457]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription i... View more >>

GO - Molecular function (MF): metal ion binding [GO:0046872]; p53 binding [GO:0002039]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; transcription regulator inhibitor activity [GO:0140416]

GO - Cellular component (CC): nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Show entries

Search:

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T339M	TCGA-DM-A1HB	COAD	TCGA	PETPNRT	DEG_SCF_FBW7_1	337:343	Mutation altering degron motif	0.8534
p.R213Q	TCGA-BS-A0UV	UCEC	TCGA	AREPLSSIN	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.7329
p.R213Q	DO42793	UCEC	ICGC	AREPLSSIN	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.7329
p.V757D	DO228338	MALY	ICGC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation altering degron motif	0.6674
p.V757D	SIDM00948	Burkitt's Lymphoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation altering degron motif	0.6674
p.V757D	ACH-002232	Lymphoma	CCLE	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation altering degron motif	0.6674
p.V757D	DG-75	haematopoietic and lymphoid tissue	COSMIC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation altering degron motif	0.6674
p.P756L	TCGA-WE-A8K4	SKCM	TCGA	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation altering degron motif	0.6471
p.P756L	DO51281	SKCM	ICGC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation altering degron motif	0.6471
p.S349T	DO234285	ESAD	ICGC	PETPNRT	DEG_SCF_FBW7_1	337:343	Mutation blocking phosphorylation signal	0.6111
p.A212V	TCGA-DA-A95Z	SKCM	TCGA	AREPLSSIN	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.5825
p.A212V	DO219481	SKCM	ICGC	AREPLSSIN	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.5825
p.S229Y	TCGA-AX-A2HC	UCEC	TCGA	AREPLSSIN	DEG_APCC_DBOX_1	212:220	Mutation blocking phosphorylation signal	0.5278
p.S229Y	DO41572	UCEC	ICGC	AREPLSSIN	DEG_APCC_DBOX_1	212:220	Mutation blocking phosphorylation signal	0.5278
p.A751T	TCGA-5U-AB0D	THYM	TCGA	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751T	ACH-001786	Colon/Colorectal Cancer	CCLE	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751D	TCGA-AP-A1DV	UCEC	TCGA	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751D	DO43186	UCEC	ICGC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751V	DO229003	COCA	ICGC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056
p.A751V	DO230659	LAML	ICGC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	752:765	Mutation rewiring degron network	0.3056

Showing 1 to 20 of 85 entries

Previous1 2 3 4 5Next

Kaplan plot for TAF3 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TAF3

UniProt ID: Q5VWG9

Entrez ID: 83860

Protein name: Transcription initiation factor TFIID subunit 3 (140 kDa TATA box-binding protein-associated factor) (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (TAF(II)140) (TAF140) (TAFII-140) (TAFII140)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for TAF3 in