DegronMD - Q5VWJ9(SNX30)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D82Y	TCGA-BS-A0UF	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.0556
p.D82Y	DO41488	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.0556
p.S71L	TCGA-EB-A41A	SKCM	TCGA	PASSS	DEG_SPOP_SBC_1	68:72	Mutation altering degron motif	0.7667
p.S71L	DO37429	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	68:72	Mutation altering degron motif	0.7667
p.G59S	TCGA-EO-A22R	UCEC	TCGA	AGTSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.2222
p.G59S	TCGA-EO-A22R	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.0833
p.G59S	DO42713	UCEC	ICGC	AGTSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.2222
p.G59S	DO42713	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.0833
p.L56F	DO942	BOCA	ICGC	AGTSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.1389
p.A69P	DO225355	BRCA	ICGC	PASSS	DEG_SPOP_SBC_1	68:72	Mutation altering degron motif	0.6392
p.D19N	DO227944	BRCA	ICGC	AGSSS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.1667
p.H15Q	SIDM00845	Burkitt's Lymphoma	GDSC	AGSSS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.0556
p.A69V	SIDM00981	B-Cell Non-Hodgkin's Lymphoma	GDSC	PASSS	DEG_SPOP_SBC_1	68:72	Mutation altering degron motif	0.5825
p.A69V	ACH-000056	Lymphoma	CCLE	PASSS	DEG_SPOP_SBC_1	68:72	Mutation altering degron motif	0.5825
p.A69V	DOHH-2	haematopoietic and lymphoid tissue	COSMIC	PASSS	DEG_SPOP_SBC_1	68:72	Mutation altering degron motif	0.5825
p.S66L	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	63:67	Mutation altering degron motif	0.8778
p.S66L	ACH-000893	Lung Cancer	CCLE	AGTSS	DEG_SPOP_SBC_1	63:67	Mutation altering degron motif	0.8778
p.S66L	NCI-H1651	lung	COSMIC	AGTSS	DEG_SPOP_SBC_1	63:67	Mutation altering degron motif	0.8778
p.P68S	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	68:72	Mutation altering degron motif	0.6752
p.P68S	ACH-000861	Lung Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	68:72	Mutation altering degron motif	0.6752
p.P68S	HOP-62	lung	COSMIC	PASSS	DEG_SPOP_SBC_1	68:72	Mutation altering degron motif	0.6752
p.R77T	ACH-001392	Breast Cancer	CCLE	AGTSS	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.0556
p.R77T	ACH-001392	Breast Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.1944
p.T61I	ACH-001540	Liposarcoma	CCLE	AGTSS	DEG_SPOP_SBC_1	63:67	Mutation blocking phosphorylation signal	0.7222
p.T61I	ACH-001540	Liposarcoma	CCLE	PASSS	DEG_SPOP_SBC_1	68:72	Mutation blocking phosphorylation signal	0.5833

Kaplan plot for SNX30 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SNX30

UniProt ID: Q5VWJ9

Entrez ID: 401548

Protein name: Sorting nexin-30

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SNX30 in