DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
MORN5
UniProt ID:
Q5VZ52
Entrez ID:
254956
Protein name:
MORN repeat-containing protein 5
External links:
UniprotKB
HGNC
RefSeq
COSMIC
Please click
HERE
for better display.
Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
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Choose a PDB ID:
Open in full screen with detailed sequence annotations
MORN5
M
E
Y
T
G
S
K
Y
I
G
E
Y
V
D
G
R
M
E
G
K
A
K
Y
I
L
P
T
E
T
I
Y
V
G
E
M
K
D
G
M
F
H
G
E
G
T
L
Y
F
P
S
G
S
Q
Y
D
A
I
W
E
N
G
L
A
I
K
G
T
Y
T
F
S
D
G
L
H
Y
D
E
K
N
W
H
Y
C
D
G
Y
D
R
R
F
Y
T
E
I
L
N
G
L
K
P
A
G
M
A
Q
L
T
N
M
D
P
P
R
K
I
P
K
G
Y
Y
D
C
G
D
G
F
Y
N
P
V
T
R
V
V
K
D
Y
R
N
R
F
L
R
N
A
D
D
D
E
H
E
W
I
T
R
T
C
R
K
G
20
40
60
80
100
120
140
160
Residue number
0
2
4
6
8
10
12
14
Number of mutated samples
0
0.5
1
1.5
2
2.5
3
Phosphorylation sites
Control panel
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Show
10
25
50
100
entries
Search:
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.T132M
DO233944
GACA
ICGC
DYR
CBL_MET
137:139
Mutation blocking phosphorylation signal
0.6389
p.R141H
TCGA-AJ-A3BH
UCEC
TCGA
DYR
CBL_MET
137:139
Mutation rewiring degron network
0.2778
p.R141H
TCGA-CJ-4907
KIRC
TCGA
DYR
CBL_MET
137:139
Mutation rewiring degron network
0.2778
p.R141H
TCGA-ED-A82E
LIHC
TCGA
DYR
CBL_MET
137:139
Mutation rewiring degron network
0.2778
p.R141H
TCGA-HU-A4H3
STAD
TCGA
DYR
CBL_MET
137:139
Mutation rewiring degron network
0.2778
p.R141H
DO233882
GACA
ICGC
DYR
CBL_MET
137:139
Mutation rewiring degron network
0.2778
p.R141H
DO19743
KIRC
ICGC
DYR
CBL_MET
137:139
Mutation rewiring degron network
0.2778
p.R141H
DO48481
LIHC
ICGC
DYR
CBL_MET
137:139
Mutation rewiring degron network
0.2778
p.R141H
DO47903
STAD
ICGC
DYR
CBL_MET
137:139
Mutation rewiring degron network
0.2778
p.R141H
DO41638
UCEC
ICGC
DYR
CBL_MET
137:139
Mutation rewiring degron network
0.2778
p.R133S
TCGA-EM-A3SZ
THCA
TCGA
DYR
CBL_MET
137:139
Mutation rewiring degron network
0.2222
p.R133S
DO48129
THCA
ICGC
DYR
CBL_MET
137:139
Mutation rewiring degron network
0.2222
p.A146T
TCGA-AX-A3G9
UCEC
TCGA
DYR
CBL_MET
137:139
Mutation rewiring degron network
0.1389
p.A146T
DO41241
UCEC
ICGC
DYR
CBL_MET
137:139
Mutation rewiring degron network
0.1389
p.A146T
SIDM00217
Colorectal Carcinoma
GDSC
DYR
CBL_MET
137:139
Mutation rewiring degron network
0.1389
p.A146T
ACH-000999
Colon/Colorectal Cancer
CCLE
DYR
CBL_MET
137:139
Mutation rewiring degron network
0.1389
p.A146T
SNU-1040
large intestine
COSMIC
DYR
CBL_MET
137:139
Mutation rewiring degron network
0.1389
p.D149Y
TCGA-A5-A2K5
UCEC
TCGA
DYR
CBL_MET
137:139
Mutation rewiring degron network
0.0556
p.D149Y
DO41379
UCEC
ICGC
DYR
CBL_MET
137:139
Mutation rewiring degron network
0.0556
Showing 1 to 19 of 19 entries
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Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for MORN5 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc