OBI1
UniProt ID: Q5W0B1
Entrez ID: 79596
Protein name: ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:...
FUNCTION: E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). {ECO:0000269|PubMed:31160578}.
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GO - Biological processes (BP):
protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513]; regulation of DNA replication [GO:0006275]...
protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513]; regulation of DNA replication [GO:0006275]
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GO - Molecular function (MF):
chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]...
chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]
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GO - Cellular component (CC):
chromatin [GO:0000785]...
chromatin [GO:0000785]
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OBI1
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Kaplan plot for OBI1 in
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*NOTE: the Kaplan plots were collected from OncoLnc