TENT4A
UniProt ID: Q5XG87
Entrez ID: 11044
Protein name: Terminal nucleotidyltransferase 4A (DNA polymerase sigma) (LAK-1) (Non-canonical poly(A) RNA polymerase PAPD7) (EC 2.7.7.19) (PAP-associated domain-containing protein 7) (TRAMP-like complex polyadenylate polymerase) (Terminal guanylyltransferase) (EC 2.7.7.-) (Terminal uridylyltransferase 5) (TUTase 5) (Topoisomerase-related function protein 4-1) (TRF4-1)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (PubMed:23376078, PubMed:30026317). Also functions as a ca...
FUNCTION: Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (PubMed:23376078, PubMed:30026317). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation (PubMed:23376078). {ECO:0000269|PubMed:23376078, ECO:0000269|PubMed:30026317}.
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GO - Biological processes (BP):
double-strand break repair [GO:0006302]; mitotic chromosome condensation [GO:0007076]; mRNA processing [GO:0006397]; negative regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060212]; positive regulation of 3'-UTR-mediated mRNA stabilization [GO:1905870]; response to xenobiotic st...
double-strand break repair [GO:0006302]; mitotic chromosome condensation [GO:0007076]; mRNA processing [GO:0006397]; negative regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060212]; positive regulation of 3'-UTR-mediated mRNA stabilization [GO:1905870]; response to xenobiotic stimulus [GO:0009410]; RNA 3'-end processing [GO:0031123]; RNA 3' uridylation [GO:0071076]; RNA polyadenylation [GO:0043631]; sister chromatid cohesion [GO:0007062]
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GO - Molecular function (MF):
ATP binding [GO:0005524]; guanylyltransferase activity [GO:0070568]; metal ion binding [GO:0046872]; polynucleotide adenylyltransferase activity [GO:0004652]; SMC family protein binding [GO:0043221]...
ATP binding [GO:0005524]; guanylyltransferase activity [GO:0070568]; metal ion binding [GO:0046872]; polynucleotide adenylyltransferase activity [GO:0004652]; SMC family protein binding [GO:0043221]
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GO - Cellular component (CC):
Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; TRAMP complex [GO:0031499]...
Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; TRAMP complex [GO:0031499]
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TENT4A
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Kaplan plot for TENT4A in
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*NOTE: the Kaplan plots were collected from OncoLnc