DegronMD - Q66K14(TBC1D9B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E989Q	TCGA-D8-A73X	BRCA	TCGA	DYR	CBL_MET	997:999	Mutation rewiring degron network	0.1111
p.T369I	TCGA-EE-A29G	SKCM	TCGA	ADSSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.0556
p.T369I	DO47303	SKCM	ICGC	ADSSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.0556
p.E353K	DO222576	COCA	ICGC	ADSSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.2778
p.P364T	DO229029	LICA	ICGC	ADSSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.1944
p.A346D	DO229032	LICA	ICGC	ADSSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.0833
p.E348K	DO50970	LICA	ICGC	ADSSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.1389
p.S363C	DO222868	MELA	ICGC	ADSSS	DEG_SPOP_SBC_1	355:359	Mutation blocking phosphorylation signal	0.6667
p.S352T	DO46783	PAEN	ICGC	ADSSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.25
p.S352F	DO51276	SKCM	ICGC	ADSSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.25
p.E351K	DO38344	STAD	ICGC	ADSSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.2222
p.S359G	DO229229	THCA	ICGC	ADSSS	DEG_SPOP_SBC_1	355:359	Mutation altering degron motif	0.6993
p.M1004T	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	997:999	Mutation rewiring degron network	0.1944
p.M1004T	SIDM01147	Gastric Carcinoma	GDSC	DYR	CBL_MET	997:999	Mutation rewiring degron network	0.1944
p.Y998C	SIDM00856	Other Solid Cancers	GDSC	DYR	CBL_MET	997:999	Mutation altering degron motif	0.8198
p.R999W	SIDM00148	Breast Carcinoma	GDSC	DYR	CBL_MET	997:999	Mutation altering degron motif	0.8634
p.L346M	SIDM01617	Endometrial Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.0833
p.L346M	ACH-000994	Endometrial/Uterine Cancer	CCLE	ADSSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.0833
p.E348D	SIDM01577	Plasma Cell Myeloma	GDSC	ADSSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.1389
p.T998M	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	997:999	Mutation altering degron motif	0.7423

Kaplan plot for TBC1D9B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TBC1D9B

UniProt ID: Q66K14

Entrez ID: 23061

Protein name: TBC1 domain family member 9B

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TBC1D9B in