DegronMD - Q68CL5(TPGS2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S273C	DO225107	BRCA	ICGC	PSTSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.0833
p.S273C	ACH-000586	Lung Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.0833
p.S285W	DO225360	BRCA	ICGC	PSTSS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.8985
p.T283A	DO222884	COCA	ICGC	PSTSS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.7139
p.G281S	SIDM00108	Melanoma	GDSC	PSTSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.3056
p.G281S	SIDM01652	Non-Cancerous	GDSC	PSTSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.3056
p.G281S	SIDM00890	Melanoma	GDSC	PSTSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.3056
p.G281S	SIDM01079	Melanoma	GDSC	PSTSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.3056
p.G281S	SIDM00510	Small Cell Lung Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.3056
p.G281S	SIDM00143	Small Cell Lung Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.3056
p.G281S	SIDM00177	Melanoma	GDSC	PSTSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.3056
p.S283T	SIDM00645	Non-Small Cell Lung Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.6005
p.S283T	NCI-H1355	lung	COSMIC	PSTSS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.6005
p.V295A	ACH-000970	Colon/Colorectal Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons