DegronMD - Q6DHV5(CC2D2B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T170M	TCGA-AP-A0LM	UCEC	TCGA	VPSSS	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.25
p.T170M	DO43306	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.25
p.G175R	TCGA-AP-A1DK	UCEC	TCGA	VPSSS	DEG_SPOP_SBC_1	173:177	Mutation altering degron motif	0.7568
p.G175R	DO42033	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	173:177	Mutation altering degron motif	0.7568
p.E187K	TCGA-ZF-A9R7	BLCA	TCGA	VPSSS	DEG_SPOP_SBC_1	173:177	Mutation substituting flanking lysine	0.1667
p.E187K	DO219064	BLCA	ICGC	VPSSS	DEG_SPOP_SBC_1	173:177	Mutation substituting flanking lysine	0.1667
p.E187K	DO229456	SKCA	ICGC	VPSSS	DEG_SPOP_SBC_1	173:177	Mutation substituting flanking lysine	0.1667
p.V181A	DO222762	COCA	ICGC	VPSSS	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.2222
p.L168F	DO229045	LICA	ICGC	VPSSS	DEG_SPOP_SBC_1	173:177	Mutation substituting flanking lysine	0.3056
p.L165P	DO52365	LUSC	ICGC	VPSSS	DEG_SPOP_SBC_1	173:177	Mutation substituting flanking lysine	0.2222
p.E174D	SIDM02053	Colorectal Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	173:177	Mutation altering degron motif	0.6758
p.L174F	SIDM00545	Melanoma	GDSC	VPSSS	DEG_SPOP_SBC_1	173:177	Mutation altering degron motif	0.6981
p.L174F	Mewo	skin	COSMIC	VPSSS	DEG_SPOP_SBC_1	173:177	Mutation altering degron motif	0.6981
p.I173V	SIDM01652	Non-Cancerous	GDSC	VPSSS	DEG_SPOP_SBC_1	173:177	Mutation altering degron motif	0.7076
p.I173V	SIDM00187	Kidney Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	173:177	Mutation altering degron motif	0.7076
p.L165Q	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	173:177	Mutation substituting flanking lysine	0.2222
p.L165Q	ACH-000766	Lung Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	173:177	Mutation substituting flanking lysine	0.2222
p.L165Q	NCI-H1648	lung	COSMIC	VPSSS	DEG_SPOP_SBC_1	173:177	Mutation substituting flanking lysine	0.2222
p.L167I	SIDM01611	Endometrial Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.1667
p.R175C	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	VPSSS	DEG_SPOP_SBC_1	173:177	Mutation altering degron motif	0.8301
p.R184H	SNU-C5	large intestine	COSMIC	VPSSS	DEG_SPOP_SBC_1	173:177	Mutation substituting flanking lysine	0.25

Kaplan plot for CC2D2B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CC2D2B

UniProt ID: Q6DHV5

Entrez ID: 387707

Protein name: Protein CC2D2B

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CC2D2B in