DegronMD - Q6EMK4(VASN)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E384K	TCGA-ER-A19M	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.0556
p.E384K	DO37798	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.0556
p.A351T	TCGA-PK-A5HB	ACC	TCGA	PATTT	DEG_SPOP_SBC_1	350:354	Mutation altering degron motif	0.6028
p.P382H	DO225170	BRCA	ICGC	ALSSS	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.1111
p.P382H	DO52560	BRCA	ICGC	ALSSS	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.1111
p.V364M	DO227996	COCA	ICGC	PATTT	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.0556
p.V364M	DO227996	COCA	ICGC	ALSSS	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.1667
p.E384A	DO229010	COCA	ICGC	ALSSS	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.0556
p.E384A	DO229013	COCA	ICGC	ALSSS	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.0556
p.E384A	DO229016	COCA	ICGC	ALSSS	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.0556
p.E384A	DO229003	COCA	ICGC	ALSSS	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.0556
p.E384A	DO220998	WT	ICGC	ALSSS	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.0556
p.A356S	DO228138	PBCA	ICGC	PATTT	DEG_SPOP_SBC_1	350:354	Mutation rewiring degron network	0.2778

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons