DegronMD - Q6GQQ9(OTUD7B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S471L	TCGA-58-8391	LUSC	TCGA	VGSSS	DEG_SPOP_SBC_1	472:476	Mutation blocking phosphorylation signal	0.75
p.S471L	DO45440	LUSC	ICGC	VGSSS	DEG_SPOP_SBC_1	472:476	Mutation blocking phosphorylation signal	0.75
p.R761M	TCGA-AJ-A23O	UCEC	TCGA	PPPY	ITCH	766:769	Mutation rewiring degron network	0.1944
p.R761M	DO43290	UCEC	ICGC	PPPY	ITCH	766:769	Mutation rewiring degron network	0.1944
p.R484W	TCGA-AP-A0LD	UCEC	TCGA	VGSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.1111
p.R484W	TCGA-VQ-A91E	STAD	TCGA	VGSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.1111
p.R484W	DO51784	STAD	ICGC	VGSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.1111
p.R484W	DO41578	UCEC	ICGC	VGSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.1111
p.G482S	TCGA-B7-A5TJ	STAD	TCGA	VGSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.1667
p.G482S	DO222329	STAD	ICGC	VGSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.1667
p.G482S	SIDM00845	Burkitt's Lymphoma	GDSC	VGSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.1667
p.E480K	TCGA-B8-A8YJ	KIRC	TCGA	VGSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.2222
p.E480K	TCGA-HT-A5RC	LGG	TCGA	VGSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.2222
p.E480K	DO49737	KIRC	ICGC	VGSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.2222
p.E480K	DO48525	LGG	ICGC	VGSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.2222
p.S474R	TCGA-BF-A5EO	SKCM	TCGA	VGSSS	DEG_SPOP_SBC_1	472:476	Mutation altering degron motif	0.7427
p.S474R	DO219450	SKCM	ICGC	VGSSS	DEG_SPOP_SBC_1	472:476	Mutation altering degron motif	0.7427
p.G762C	TCGA-CV-6933	HNSC	TCGA	PPPY	ITCH	766:769	Mutation rewiring degron network	0.2222
p.G762C	DO14164	HNSC	ICGC	PPPY	ITCH	766:769	Mutation rewiring degron network	0.2222
p.S774F	TCGA-EB-A5UL	SKCM	TCGA	PPPY	ITCH	766:769	Mutation rewiring degron network	0.1944
p.S774F	DO47601	SKCM	ICGC	PPPY	ITCH	766:769	Mutation rewiring degron network	0.1944
p.S774F	SIDM00857	Melanoma	GDSC	PPPY	ITCH	766:769	Mutation rewiring degron network	0.1944
p.S774F	ACH-000572	Skin Cancer	CCLE	PPPY	ITCH	766:769	Mutation rewiring degron network	0.1944
p.S774F	G-361	skin	COSMIC	PPPY	ITCH	766:769	Mutation rewiring degron network	0.1944
p.Y769H	TCGA-RD-A8NB	STAD	TCGA	PPPY	ITCH	766:769	Mutation altering degron motif	0.7229
p.Y769H	DO50142	STAD	ICGC	PPPY	ITCH	766:769	Mutation altering degron motif	0.7229
p.R761G	TCGA-SX-A7SU	KIRP	TCGA	PPPY	ITCH	766:769	Mutation rewiring degron network	0.1944
p.R761G	DO49796	KIRP	ICGC	PPPY	ITCH	766:769	Mutation rewiring degron network	0.1944
p.S475R	TCGA-UY-A9PE	BLCA	TCGA	VGSSS	DEG_SPOP_SBC_1	472:476	Mutation altering degron motif	0.7427
p.S475R	DO219043	BLCA	ICGC	VGSSS	DEG_SPOP_SBC_1	472:476	Mutation altering degron motif	0.7427
p.P767H	DO228986	LICA	ICGC	PPPY	ITCH	766:769	Mutation altering degron motif	0.7694
p.P767T	DO229041	LICA	ICGC	PPPY	ITCH	766:769	Mutation altering degron motif	0.7031
p.P767T	SIDM00442	Thyroid Gland Carcinoma	GDSC	PPPY	ITCH	766:769	Mutation altering degron motif	0.7031
p.P767T	ACH-000058	Thyroid Cancer	CCLE	PPPY	ITCH	766:769	Mutation altering degron motif	0.7031
p.P767T	ML-1	thyroid	COSMIC	PPPY	ITCH	766:769	Mutation altering degron motif	0.7031
p.R483L	DO232761	PBCA	ICGC	VGSSS	DEG_SPOP_SBC_1	472:476	Mutation rewiring degron network	0.1389
p.S476F	ACH-000809	Esophageal Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	472:476	Mutation altering degron motif	0.7982
p.S776N	ACH-001063	Ovarian Cancer	CCLE	PPPY	ITCH	766:769	Mutation rewiring degron network	0.1389

Kaplan plot for OTUD7B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OTUD7B

UniProt ID: Q6GQQ9

Entrez ID: 56957

Protein name: OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OTUD7B in