DegronMD - Q6IEE8(SLFN12L)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L385I	TCGA-AN-A046	BRCA	TCGA	PASTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.0833
p.L385I	DO1285	BRCA	ICGC	PASTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.0833
p.S371Y	TCGA-EO-A22X	UCEC	TCGA	PASTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.3056
p.V371M	DO13192	GBM	ICGC	PASTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.3056
p.V371M	DO35959	PBCA	ICGC	PASTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.3056
p.L369M	DO229019	LICA	ICGC	PASTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.25
p.V371L	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.3056
p.V371L	NCI-H1770	lung	COSMIC	PASTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.3056
p.S377L	ACH-002215	Lymphoma	CCLE	PASTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.3056
p.S377L	BC-3	haematopoietic and lymphoid tissue	COSMIC	PASTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.3056

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons