RADX
UniProt ID: Q6NSI4
Entrez ID: 55086
Protein name: RPA-related protein RADX (RPA-related and RAD51-antagonist, X-chromosome)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability (PubMed:28735897). Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity ...
FUNCTION: Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability (PubMed:28735897). Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks (PubMed:28735897). {ECO:0000269|PubMed:28735897}.
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GO - Biological processes (BP):
negative regulation of double-strand break repair via homologous recombination [GO:2000042]; regulation of DNA repair [GO:0006282]...
negative regulation of double-strand break repair via homologous recombination [GO:2000042]; regulation of DNA repair [GO:0006282]
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GO - Molecular function (MF):
RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]...
RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]
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GO - Cellular component (CC):
nuclear speck [GO:0016607]; replication fork [GO:0005657]...
nuclear speck [GO:0016607]; replication fork [GO:0005657]
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RADX
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*NOTE: the Kaplan plots were collected from OncoLnc