DegronMD - Q6NT52(CGB2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P147S	TCGA-D3-A8GL	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.1111
p.P147S	DO50287	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.1111
p.A135D	DO229465	SKCA	ICGC	ASSSS	DEG_SPOP_SBC_1	135:139	Mutation altering degron motif	0.7793
p.P149S	SIDM00007	Other Solid Cancers	GDSC	ASSSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.0556
p.P149S	MCC13	skin	COSMIC	ASSSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.0556
p.P143L	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.2222
p.P143L	KYSE-410	oesophagus	COSMIC	ASSSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.2222
p.A141T	SIDM00564	Ovarian Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.2778
p.A141T	ACH-000527	Ovarian Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.2778
p.A141T	OVISE	ovary	COSMIC	ASSSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons