DegronMD - Q6NW40(RGMB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R160M	TCGA-AP-A1DK	UCEC	TCGA	PPSY	ITCH	157:160	Mutation altering degron motif	0.8632
p.R160M	TCGA-BR-4370	STAD	TCGA	PPSY	ITCH	157:160	Mutation altering degron motif	0.8632
p.R127C	TCGA-CG-4306	STAD	TCGA	PTSST	DEG_SPOP_SBC_1	126:130	Mutation altering degron motif	0.8301
p.R127C	DO38567	STAD	ICGC	PTSST	DEG_SPOP_SBC_1	126:130	Mutation altering degron motif	0.8301
p.R135Q	TCGA-CN-6996	HNSC	TCGA	PTSST	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.1944
p.R135Q	DO14305	HNSC	ICGC	PTSST	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.1944
p.H147D	TCGA-DD-A11D	LIHC	TCGA	PPSY	ITCH	157:160	Mutation rewiring degron network	0.0556
p.Q159H	TCGA-EE-A29G	SKCM	TCGA	PPSY	ITCH	157:160	Mutation altering degron motif	0.7582
p.P126L	DO234401	ESAD	ICGC	PTSST	DEG_SPOP_SBC_1	126:130	Mutation altering degron motif	0.7582
p.M116T	DO228949	LICA	ICGC	PTSST	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.0556
p.R148M	DO37703	SKCM	ICGC	PPSY	ITCH	157:160	Mutation rewiring degron network	0.0833
p.Q118H	DO47303	SKCM	ICGC	PTSST	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.1111
p.R119M	DO38499	STAD	ICGC	PTSST	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.1389
p.R119M	DO42033	UCEC	ICGC	PTSST	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.1389
p.S170C	ACH-001410	Bladder Cancer	CCLE	PPSY	ITCH	157:160	Mutation rewiring degron network	0.0556
p.G167E	KM12	large intestine	COSMIC	PPSY	ITCH	157:160	Mutation rewiring degron network	0.1389
p.D137H	NCI-H187	lung	COSMIC	PTSST	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.1389
p.E133K	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	PTSST	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.25

Kaplan plot for RGMB in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RGMB

UniProt ID: Q6NW40

Entrez ID: 285704

Protein name: Repulsive guidance molecule B (DRG11-responsive axonal guidance and outgrowth of neurite) (DRAGON)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RGMB in