DegronMD - Q6NXG1(ESRP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P545Q	TCGA-37-3789	LUSC	TCGA	PPSY	ITCH	554:557	Mutation rewiring degron network	0.0833
p.P545Q	DO26743	LUSC	ICGC	PPSY	ITCH	554:557	Mutation rewiring degron network	0.0833
p.V565L	TCGA-86-6851	LUAD	TCGA	PPSY	ITCH	554:557	Mutation rewiring degron network	0.1111
p.P562S	TCGA-BA-5152	HNSC	TCGA	PPSY	ITCH	554:557	Mutation rewiring degron network	0.1944
p.P545L	TCGA-DD-AAVQ	LIHC	TCGA	PPSY	ITCH	554:557	Mutation rewiring degron network	0.0833
p.P545L	DO52276	LIHC	ICGC	PPSY	ITCH	554:557	Mutation rewiring degron network	0.0833
p.P546S	TCGA-EY-A215	UCEC	TCGA	PPSY	ITCH	554:557	Mutation rewiring degron network	0.1111
p.P546S	DO42665	UCEC	ICGC	PPSY	ITCH	554:557	Mutation rewiring degron network	0.1111
p.S556F	TCGA-HU-A4H3	STAD	TCGA	PPSY	ITCH	554:557	Mutation altering degron motif	0.6871
p.C551R	TCGA-LL-A7SZ	BRCA	TCGA	PPSY	ITCH	554:557	Mutation rewiring degron network	0.25
p.C551R	DO50064	BRCA	ICGC	PPSY	ITCH	554:557	Mutation rewiring degron network	0.25
p.P554S	TCGA-XF-A9SK	BLCA	TCGA	PPSY	ITCH	554:557	Mutation altering degron motif	0.6752
p.P550S	DO223596	BLCA	ICGC	PPSY	ITCH	554:557	Mutation rewiring degron network	0.2222
p.F555S	DO5012	BRCA	ICGC	PPSY	ITCH	554:557	Mutation altering degron motif	0.7982
p.A566T	DO8642	COAD	ICGC	PPSY	ITCH	554:557	Mutation rewiring degron network	0.0833
p.A566T	DO47925	STAD	ICGC	PPSY	ITCH	554:557	Mutation rewiring degron network	0.0833
p.A566D	DO10880	GBM	ICGC	PPSY	ITCH	554:557	Mutation rewiring degron network	0.0833
p.P558S	DO14393	HNSC	ICGC	PPSY	ITCH	554:557	Mutation rewiring degron network	0.3056
p.A567S	DO229032	LICA	ICGC	PPSY	ITCH	554:557	Mutation rewiring degron network	0.0556
p.V561L	DO23798	LUAD	ICGC	PPSY	ITCH	554:557	Mutation rewiring degron network	0.2222
p.T564A	DO228294	MALY	ICGC	PPSY	ITCH	554:557	Mutation rewiring degron network	0.1389
p.P563A	DO229467	SKCA	ICGC	PPSY	ITCH	554:557	Mutation rewiring degron network	0.1667
p.P563L	DO229467	SKCA	ICGC	PPSY	ITCH	554:557	Mutation rewiring degron network	0.1667
p.S552F	DO47903	STAD	ICGC	PPSY	ITCH	554:557	Mutation rewiring degron network	0.2778
p.C547F	SIDM00193	Colorectal Carcinoma	GDSC	PPSY	ITCH	554:557	Mutation rewiring degron network	0.1389
p.C547F	ACH-000991	Colon/Colorectal Cancer	CCLE	PPSY	ITCH	554:557	Mutation rewiring degron network	0.1389
p.C547F	SNU-81	large intestine	COSMIC	PPSY	ITCH	554:557	Mutation rewiring degron network	0.1389
p.A567V	SNU-175	large intestine	COSMIC	PPSY	ITCH	554:557	Mutation rewiring degron network	0.0556

Kaplan plot for ESRP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ESRP1

UniProt ID: Q6NXG1

Entrez ID: 54845

Protein name: Epithelial splicing regulatory protein 1 (RNA-binding motif protein 35A) (RNA-binding protein 35A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ESRP1 in