DegronMD - Q6P499(NIPAL3)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S20P	TCGA-A5-A1OF	UCEC	TCGA	PPTSS	DEG_SPOP_SBC_1	15:19	Mutation rewiring degron network	0.3056
p.S20P	DO42568	UCEC	ICGC	PPTSS	DEG_SPOP_SBC_1	15:19	Mutation rewiring degron network	0.3056
p.A22T	TCGA-AP-A056	UCEC	TCGA	PPTSS	DEG_SPOP_SBC_1	15:19	Mutation rewiring degron network	0.25
p.A22T	DO43971	UCEC	ICGC	PPTSS	DEG_SPOP_SBC_1	15:19	Mutation rewiring degron network	0.25
p.P15H	TCGA-EC-A1QX	UCEC	TCGA	PPTSS	DEG_SPOP_SBC_1	15:19	Mutation altering degron motif	0.7694
p.P15H	DO42592	UCEC	ICGC	PPTSS	DEG_SPOP_SBC_1	15:19	Mutation altering degron motif	0.7694
p.A8T	TCGA-FI-A2D5	UCEC	TCGA	PPTSS	DEG_SPOP_SBC_1	15:19	Mutation rewiring degron network	0.1389
p.A8T	DO41331	UCEC	ICGC	PPTSS	DEG_SPOP_SBC_1	15:19	Mutation rewiring degron network	0.1389
p.L9M	TCGA-FS-A1ZM	SKCM	TCGA	PPTSS	DEG_SPOP_SBC_1	15:19	Mutation rewiring degron network	0.1667
p.A22V	ACH-002647	Gastric Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	15:19	Mutation rewiring degron network	0.25
p.V21M	MY-M12	haematopoietic and lymphoid tissue	COSMIC	PPTSS	DEG_SPOP_SBC_1	15:19	Mutation rewiring degron network	0.2778
p.V21M	JHOS-3	ovary	COSMIC	PPTSS	DEG_SPOP_SBC_1	15:19	Mutation rewiring degron network	0.2778
p.V21M	NEC8	testis	COSMIC	PPTSS	DEG_SPOP_SBC_1	15:19	Mutation rewiring degron network	0.2778
p.V21M	AMO-1	haematopoietic and lymphoid tissue	COSMIC	PPTSS	DEG_SPOP_SBC_1	15:19	Mutation rewiring degron network	0.2778
p.A10T	CML-T1	haematopoietic and lymphoid tissue	COSMIC	PPTSS	DEG_SPOP_SBC_1	15:19	Mutation substituting flanking lysine	0.3056

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons