DegronMD - Q6PEV8(FAM199X)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S281R	TCGA-21-1076	LUSC	TCGA	ASSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.3056
p.S281R	DO26599	LUSC	ICGC	ASSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.3056
p.S296T	TCGA-92-8063	LUSC	TCGA	ASSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.0556
p.S296T	DO26941	LUSC	ICGC	ASSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.0556
p.A282T	TCGA-HC-7747	PRAD	TCGA	ASSSS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.7139
p.A282T	DO36225	PRAD	ICGC	ASSSS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.7139
p.S288C	DO229250	THCA	ICGC	ASSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.2778
p.A278V	SIDM02059	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.2222
p.S281G	SIDM00933	Breast Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.3056
p.S281G	ACH-000856	Breast Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.3056
p.S281G	CAL-51	breast	COSMIC	ASSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.3056
p.A280T	ACH-002004	Skin Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons