DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
KCTD18
UniProt ID:
Q6PI47
Entrez ID:
130535
Protein name:
BTB/POZ domain-containing protein KCTD18
External links:
UniprotKB
HGNC
RefSeq
COSMIC
Please click
HERE
for better display.
Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
...
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GO - Biological processes (BP):
protein homooligomerization [GO:0051260]...
protein homooligomerization [GO:0051260]
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GO - Molecular function (MF):
...
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GO - Cellular component (CC):
...
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Choose a PDB ID:
Open in full screen with detailed sequence annotations
KCTD18
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Phosphorylation
Legend: PTM sites
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.K274T
TCGA-IB-7651
PAAD
TCGA
PSTST
DEG_SPOP_SBC_1
281:285
Mutation substituting flanking lysine
0.25
p.K274T
DO46657
PAAD
ICGC
PSTST
DEG_SPOP_SBC_1
281:285
Mutation substituting flanking lysine
0.25
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for KCTD18 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc