DegronMD - Q6PJQ5(FOXR2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K143R	TCGA-28-2506	GBM	TCGA	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation substituting flanking lysine	0.25
p.K143R	DO11585	GBM	ICGC	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation substituting flanking lysine	0.25
p.P132S	TCGA-AA-3984	COAD	TCGA	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.6752
p.P132S	TCGA-B5-A11E	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.6752
p.P132S	TCGA-EO-A22R	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.6752
p.P132S	DO9002	COAD	ICGC	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.6752
p.P132S	DO41644	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.6752
p.P132S	DO42713	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.6752
p.S139F	TCGA-AX-A2HC	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.25
p.S139F	DO41572	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.25
p.P132Q	TCGA-CD-A4MH	STAD	TCGA	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.7035
p.P132Q	DO47751	STAD	ICGC	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.7035
p.E124K	TCGA-D9-A148	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.1111
p.E124K	TCGA-XF-A9SJ	BLCA	TCGA	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.1111
p.E124K	DO219045	BLCA	ICGC	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.1111
p.E124K	DO37971	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.1111
p.S134F	TCGA-EB-A4XL	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.7982
p.S134F	TCGA-EE-A29R	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.7982
p.S134F	DO220899	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.7982
p.S134F	DO37448	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.7982
p.S134F	DO47401	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.7982
p.P140S	TCGA-EE-A29E	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.2222
p.P140S	TCGA-EE-A2GS	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.2222
p.P140S	DO37831	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.2222
p.P140S	DO37465	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.2222
p.S135Y	TCGA-EO-A3AY	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.712
p.S135Y	DO43202	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.712
p.S135F	TCGA-WJ-A86L	LIHC	TCGA	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.7982
p.S135F	DO52325	LIHC	ICGC	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.7982
p.Q142H	DO233089	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.1667
p.D125N	DO222413	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.1389
p.E129K	DO229462	SKCA	ICGC	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.25
p.L131V	SIDM00267	Biliary Tract Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.3056
p.L131V	ACH-002312	Gallbladder Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.3056
p.L131V	TGBC24TKB	biliary tract	COSMIC	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.3056
p.S135C	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.7541
p.S135C	ACH-000030	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.7541
p.S135C	PC-14	lung	COSMIC	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.7541
p.P140L	ACH-001300	Neuroblastoma	CCLE	PSSSS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FOXR2

UniProt ID: Q6PJQ5

Entrez ID: 139628

Protein name: Forkhead box protein R2 (Forkhead box protein N6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FOXR2 in