DegronMD - Q6UB99(ANKRD11)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A1751G	TCGA-20-0991	OV	TCGA	DSQHSTPVPTA	DEG_COP1_1	1741:1751	Mutation altering degron motif	0.754
p.A1751G	DO31949	OV	ICGC	DSQHSTPVPTA	DEG_COP1_1	1741:1751	Mutation altering degron motif	0.754
p.A1864T	TCGA-2W-A8YY	CESC	TCGA	VTVTPSPE	DEG_SCF_FBW7_2	1873:1880	Mutation rewiring degron network	0.0833
p.A1864T	DO223732	CESC	ICGC	VTVTPSPE	DEG_SCF_FBW7_2	1873:1880	Mutation rewiring degron network	0.0833
p.S892R	TCGA-34-2596	LUSC	TCGA	DYR	CBL_MET	899:901	Mutation rewiring degron network	0.1389
p.S892R	DO26508	LUSC	ICGC	DYR	CBL_MET	899:901	Mutation rewiring degron network	0.1389
p.D1738H	TCGA-4Z-AA87	BLCA	TCGA	DSQHSTPVPTA	DEG_COP1_1	1741:1751	Mutation rewiring degron network	0.25
p.D1738H	TCGA-4Z-AA87	BLCA	TCGA	PRTPSCS	DEG_SCF_FBW7_1	1722:1728	Mutation rewiring degron network	0.0556
p.D1738H	DO218990	BLCA	ICGC	DSQHSTPVPTA	DEG_COP1_1	1741:1751	Mutation rewiring degron network	0.25
p.D1738H	DO218990	BLCA	ICGC	PRTPSCS	DEG_SCF_FBW7_1	1722:1728	Mutation rewiring degron network	0.0556
p.S860L	TCGA-55-A4DF	LUAD	TCGA	DYR	CBL_MET	864:866	Mutation blocking phosphorylation signal	0.6667
p.S860L	TCGA-CD-5800	STAD	TCGA	DYR	CBL_MET	864:866	Mutation blocking phosphorylation signal	0.6667
p.S860L	DO45318	LUAD	ICGC	DYR	CBL_MET	864:866	Mutation blocking phosphorylation signal	0.6667
p.S860L	DO38431	STAD	ICGC	DYR	CBL_MET	864:866	Mutation blocking phosphorylation signal	0.6667
p.R1797S	TCGA-66-2766	LUSC	TCGA	IRRTPEEE	DEG_SCF_FBW7_2	1795:1802	Mutation altering degron motif	0.6316
p.R1797S	DO27747	LUSC	ICGC	IRRTPEEE	DEG_SCF_FBW7_2	1795:1802	Mutation altering degron motif	0.6316
p.S1757F	TCGA-A5-A0G2	UCEC	TCGA	DSQHSTPVPTA	DEG_COP1_1	1741:1751	Mutation rewiring degron network	0.1667
p.S1757F	TCGA-F7-A61S	HNSC	TCGA	DSQHSTPVPTA	DEG_COP1_1	1741:1751	Mutation rewiring degron network	0.1667
p.S1757F	DO44427	HNSC	ICGC	DSQHSTPVPTA	DEG_COP1_1	1741:1751	Mutation rewiring degron network	0.1667
p.S1757F	DO41235	UCEC	ICGC	DSQHSTPVPTA	DEG_COP1_1	1741:1751	Mutation rewiring degron network	0.1667
p.S525F	TCGA-A5-A0G2	UCEC	TCGA	ASSTS	DEG_SPOP_SBC_1	520:524	Mutation rewiring degron network	0.3056
p.S525F	DO41235	UCEC	ICGC	ASSTS	DEG_SPOP_SBC_1	520:524	Mutation rewiring degron network	0.3056
p.S1878P	TCGA-A6-5667	COAD	TCGA	VTVTPSPE	DEG_SCF_FBW7_2	1873:1880	Mutation altering degron motif	0.6752
p.S1878P	DO9868	COAD	ICGC	VTVTPSPE	DEG_SCF_FBW7_2	1873:1880	Mutation altering degron motif	0.6752
p.E303K	TCGA-A7-A0CE	BRCA	TCGA	APSSS	DEG_SPOP_SBC_1	309:313	Mutation rewiring degron network	0.1667
p.E303K	DO4080	BRCA	ICGC	APSSS	DEG_SPOP_SBC_1	309:313	Mutation rewiring degron network	0.1667
p.E1717K	TCGA-AC-A23H	BRCA	TCGA	PRTPSCS	DEG_SCF_FBW7_1	1722:1728	Mutation rewiring degron network	0.1944
p.E1717K	DO2401	BRCA	ICGC	PRTPSCS	DEG_SCF_FBW7_1	1722:1728	Mutation rewiring degron network	0.1944
p.P1869L	TCGA-AJ-A3EK	UCEC	TCGA	VTVTPSPE	DEG_SCF_FBW7_2	1873:1880	Mutation rewiring degron network	0.2222
p.P1869L	DO41584	UCEC	ICGC	VTVTPSPE	DEG_SCF_FBW7_2	1873:1880	Mutation rewiring degron network	0.2222
p.S524L	TCGA-AN-A0AK	BRCA	TCGA	ASSTS	DEG_SPOP_SBC_1	520:524	Mutation altering degron motif	0.7667
p.S524L	DO1608	BRCA	ICGC	ASSTS	DEG_SPOP_SBC_1	520:524	Mutation altering degron motif	0.7667
p.S524L	ACH-000128	Brain Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	520:524	Mutation altering degron motif	0.7667
p.A1840V	TCGA-AP-A1DO	UCEC	TCGA	DRAPLPPVP	DEG_APCC_DBOX_1	1831:1839	Mutation rewiring degron network	0.3056
p.A1840V	DO43250	UCEC	ICGC	DRAPLPPVP	DEG_APCC_DBOX_1	1831:1839	Mutation rewiring degron network	0.3056
p.A1840V	SIDM01016	T-Lymphoblastic Leukemia	GDSC	DRAPLPPVP	DEG_APCC_DBOX_1	1831:1839	Mutation rewiring degron network	0.3056
p.A1840V	ACH-000995	Leukemia	CCLE	DRAPLPPVP	DEG_APCC_DBOX_1	1831:1839	Mutation rewiring degron network	0.3056
p.A1840V	Jurkat	haematopoietic and lymphoid tissue	COSMIC	DRAPLPPVP	DEG_APCC_DBOX_1	1831:1839	Mutation rewiring degron network	0.3056
p.E1800K	TCGA-AP-A1E0	UCEC	TCGA	IRRTPEEE	DEG_SCF_FBW7_2	1795:1802	Mutation altering degron motif	0.591
p.E1800K	DO43154	UCEC	ICGC	IRRTPEEE	DEG_SCF_FBW7_2	1795:1802	Mutation altering degron motif	0.591
p.E1800K	SIDM00791	Chronic Myelogenous Leukemia	GDSC	IRRTPEEE	DEG_SCF_FBW7_2	1795:1802	Mutation altering degron motif	0.591
p.E1800K	ACH-000551	Leukemia	CCLE	IRRTPEEE	DEG_SCF_FBW7_2	1795:1802	Mutation altering degron motif	0.591
p.E1800K	ACH-002061	Leukemia	CCLE	IRRTPEEE	DEG_SCF_FBW7_2	1795:1802	Mutation altering degron motif	0.591
p.E1800K	K-562	haematopoietic and lymphoid tissue	COSMIC	IRRTPEEE	DEG_SCF_FBW7_2	1795:1802	Mutation altering degron motif	0.591
p.A309T	TCGA-AX-A0J0	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	309:313	Mutation altering degron motif	0.7139
p.A309T	DO41133	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	309:313	Mutation altering degron motif	0.7139
p.C1712W	TCGA-AZ-5407	COAD	TCGA	PRTPSCS	DEG_SCF_FBW7_1	1722:1728	Mutation rewiring degron network	0.0556
p.C1712W	DO8432	COAD	ICGC	PRTPSCS	DEG_SCF_FBW7_1	1722:1728	Mutation rewiring degron network	0.0556
p.K29N	TCGA-B5-A1MX	UCEC	TCGA	LTKTPKLE	DEG_SCF_FBW7_2	36:43	Mutation substituting flanking lysine	0.25
p.K510N	TCGA-B5-A3FA	UCEC	TCGA	ASSTS	DEG_SPOP_SBC_1	520:524	Mutation substituting flanking lysine	0.1667
p.K510N	DO52402	UCEC	ICGC	ASSTS	DEG_SPOP_SBC_1	520:524	Mutation substituting flanking lysine	0.1667
p.A1733V	TCGA-B5-A3FC	UCEC	TCGA	DSQHSTPVPTA	DEG_COP1_1	1741:1751	Mutation rewiring degron network	0.1111
p.A1733V	TCGA-B5-A3FC	UCEC	TCGA	PRTPSCS	DEG_SCF_FBW7_1	1722:1728	Mutation rewiring degron network	0.1944
p.A1733V	DO41871	UCEC	ICGC	DSQHSTPVPTA	DEG_COP1_1	1741:1751	Mutation rewiring degron network	0.1111
p.A1733V	DO41871	UCEC	ICGC	PRTPSCS	DEG_SCF_FBW7_1	1722:1728	Mutation rewiring degron network	0.1944
p.A1733V	SIDM00238	Ovarian Carcinoma	GDSC	DSQHSTPVPTA	DEG_COP1_1	1741:1751	Mutation rewiring degron network	0.1111
p.A1733V	SIDM00238	Ovarian Carcinoma	GDSC	PRTPSCS	DEG_SCF_FBW7_1	1722:1728	Mutation rewiring degron network	0.1944
p.D1794Y	TCGA-BA-A6DA	HNSC	TCGA	IRRTPEEE	DEG_SCF_FBW7_2	1795:1802	Mutation rewiring degron network	0.3056
p.D1794Y	DO44448	HNSC	ICGC	IRRTPEEE	DEG_SCF_FBW7_2	1795:1802	Mutation rewiring degron network	0.3056
p.H526Y	TCGA-BK-A0C9	UCEC	TCGA	ASSTS	DEG_SPOP_SBC_1	520:524	Mutation rewiring degron network	0.2778
p.H526Y	DO41253	UCEC	ICGC	ASSTS	DEG_SPOP_SBC_1	520:524	Mutation rewiring degron network	0.2778
p.K1889E	TCGA-BR-4361	STAD	TCGA	VTVTPSPE	DEG_SCF_FBW7_2	1873:1880	Mutation substituting flanking lysine	0.1944
p.K1889E	DO38887	STAD	ICGC	VTVTPSPE	DEG_SCF_FBW7_2	1873:1880	Mutation substituting flanking lysine	0.1944
p.K1889E	SIDM00588	Oral Cavity Carcinoma	GDSC	VTVTPSPE	DEG_SCF_FBW7_2	1873:1880	Mutation substituting flanking lysine	0.1944
p.K1889E	SIDM01199	Hepatocellular Carcinoma	GDSC	VTVTPSPE	DEG_SCF_FBW7_2	1873:1880	Mutation substituting flanking lysine	0.1944
p.K1889E	SIDM00292	Small Cell Lung Carcinoma	GDSC	VTVTPSPE	DEG_SCF_FBW7_2	1873:1880	Mutation substituting flanking lysine	0.1944
p.K1889E	SIDM00469	Pancreatic Carcinoma	GDSC	VTVTPSPE	DEG_SCF_FBW7_2	1873:1880	Mutation substituting flanking lysine	0.1944
p.K1889E	SIDM01433	Kidney Carcinoma	GDSC	VTVTPSPE	DEG_SCF_FBW7_2	1873:1880	Mutation substituting flanking lysine	0.1944
p.K1889E	PSN1	pancreas	COSMIC	VTVTPSPE	DEG_SCF_FBW7_2	1873:1880	Mutation substituting flanking lysine	0.1944
p.K1889E	LU-165	lung	COSMIC	VTVTPSPE	DEG_SCF_FBW7_2	1873:1880	Mutation substituting flanking lysine	0.1944
p.K1889E	SNU-423	liver	COSMIC	VTVTPSPE	DEG_SCF_FBW7_2	1873:1880	Mutation substituting flanking lysine	0.1944
p.R893Q	TCGA-CD-8527	STAD	TCGA	DYR	CBL_MET	899:901	Mutation rewiring degron network	0.1667
p.R893Q	DO47739	STAD	ICGC	DYR	CBL_MET	899:901	Mutation rewiring degron network	0.1667
p.L36V	TCGA-CR-7374	HNSC	TCGA	LTKTPKLE	DEG_SCF_FBW7_2	36:43	Mutation altering degron motif	0.5654
p.L36V	DO15334	HNSC	ICGC	LTKTPKLE	DEG_SCF_FBW7_2	36:43	Mutation altering degron motif	0.5654
p.G2061W	TCGA-CR-7385	HNSC	TCGA	AISTS	DEG_SPOP_SBC_1	2047:2051	Mutation rewiring degron network	0.0556
p.G2061W	DO14282	HNSC	ICGC	AISTS	DEG_SPOP_SBC_1	2047:2051	Mutation rewiring degron network	0.0556
p.P1752S	TCGA-D9-A4Z6	SKCM	TCGA	DSQHSTPVPTA	DEG_COP1_1	1741:1751	Mutation rewiring degron network	0.3056
p.P1752S	DO47485	SKCM	ICGC	DSQHSTPVPTA	DEG_COP1_1	1741:1751	Mutation rewiring degron network	0.3056
p.D1863G	TCGA-DX-AB2Q	SARC	TCGA	VTVTPSPE	DEG_SCF_FBW7_2	1873:1880	Mutation rewiring degron network	0.0556
p.D1863G	DO220087	SARC	ICGC	VTVTPSPE	DEG_SCF_FBW7_2	1873:1880	Mutation rewiring degron network	0.0556
p.S1790L	TCGA-E6-A1LX	UCEC	TCGA	IRRTPEEE	DEG_SCF_FBW7_2	1795:1802	Mutation blocking phosphorylation signal	0.6389
p.S1790L	DO34120	PACA	ICGC	IRRTPEEE	DEG_SCF_FBW7_2	1795:1802	Mutation blocking phosphorylation signal	0.6389
p.S1790L	DO41020	UCEC	ICGC	IRRTPEEE	DEG_SCF_FBW7_2	1795:1802	Mutation blocking phosphorylation signal	0.6389
p.R906Q	TCGA-E6-A1LX	UCEC	TCGA	DYR	CBL_MET	899:901	Mutation rewiring degron network	0.1944
p.R906Q	DO41020	UCEC	ICGC	DYR	CBL_MET	899:901	Mutation rewiring degron network	0.1944
p.S517F	TCGA-EB-A431	SKCM	TCGA	ASSTS	DEG_SPOP_SBC_1	520:524	Mutation rewiring degron network	0.25
p.S517F	DO37671	SKCM	ICGC	ASSTS	DEG_SPOP_SBC_1	520:524	Mutation rewiring degron network	0.25
p.D1863N	TCGA-EO-A22R	UCEC	TCGA	VTVTPSPE	DEG_SCF_FBW7_2	1873:1880	Mutation rewiring degron network	0.0556
p.D1863N	DO42713	UCEC	ICGC	VTVTPSPE	DEG_SCF_FBW7_2	1873:1880	Mutation rewiring degron network	0.0556
p.H526R	TCGA-EO-A3B0	UCEC	TCGA	ASSTS	DEG_SPOP_SBC_1	520:524	Mutation rewiring degron network	0.2778
p.H526R	DO219773	UCEC	ICGC	ASSTS	DEG_SPOP_SBC_1	520:524	Mutation rewiring degron network	0.2778
p.A1833V	TCGA-FI-A2D5	UCEC	TCGA	DRAPLPPVP	DEG_APCC_DBOX_1	1831:1839	Mutation altering degron motif	0.5825
p.A1833V	DO50383	ESAD	ICGC	DRAPLPPVP	DEG_APCC_DBOX_1	1831:1839	Mutation altering degron motif	0.5825
p.A1833V	DO41331	UCEC	ICGC	DRAPLPPVP	DEG_APCC_DBOX_1	1831:1839	Mutation altering degron motif	0.5825
p.K786T	TCGA-FI-A2D5	UCEC	TCGA	KEKIFKE	LIG_APCC_ABBAyCdc20_2	791:797	Mutation substituting flanking lysine	0.3056
p.K786T	DO41331	UCEC	ICGC	KEKIFKE	LIG_APCC_ABBAyCdc20_2	791:797	Mutation substituting flanking lysine	0.3056
p.A1729T	TCGA-G4-6302	COAD	TCGA	PRTPSCS	DEG_SCF_FBW7_1	1722:1728	Mutation rewiring degron network	0.3056
p.A1729T	DO8778	COAD	ICGC	PRTPSCS	DEG_SCF_FBW7_1	1722:1728	Mutation rewiring degron network	0.3056
p.A1729T	SIDM00596	Endometrial Carcinoma	GDSC	PRTPSCS	DEG_SCF_FBW7_1	1722:1728	Mutation rewiring degron network	0.3056
p.A1729T	ACH-000941	Endometrial/Uterine Cancer	CCLE	PRTPSCS	DEG_SCF_FBW7_1	1722:1728	Mutation rewiring degron network	0.3056
p.A1729T	ACH-000954	Endometrial/Uterine Cancer	CCLE	PRTPSCS	DEG_SCF_FBW7_1	1722:1728	Mutation rewiring degron network	0.3056
p.A1729T	ACH-001517	Endometrial/Uterine Cancer	CCLE	PRTPSCS	DEG_SCF_FBW7_1	1722:1728	Mutation rewiring degron network	0.3056
p.A1729T	ACH-001518	Endometrial/Uterine Cancer	CCLE	PRTPSCS	DEG_SCF_FBW7_1	1722:1728	Mutation rewiring degron network	0.3056
p.A1729T	HEC-1	endometrium	COSMIC	PRTPSCS	DEG_SCF_FBW7_1	1722:1728	Mutation rewiring degron network	0.3056
p.E303Q	TCGA-HC-8259	PRAD	TCGA	APSSS	DEG_SPOP_SBC_1	309:313	Mutation rewiring degron network	0.1667
p.E303Q	DO49816	PRAD	ICGC	APSSS	DEG_SPOP_SBC_1	309:313	Mutation rewiring degron network	0.1667
p.A1733T	TCGA-JW-AAVH	CESC	TCGA	DSQHSTPVPTA	DEG_COP1_1	1741:1751	Mutation rewiring degron network	0.1111
p.A1733T	TCGA-JW-AAVH	CESC	TCGA	PRTPSCS	DEG_SCF_FBW7_1	1722:1728	Mutation rewiring degron network	0.1944
p.A1733T	DO51605	CESC	ICGC	DSQHSTPVPTA	DEG_COP1_1	1741:1751	Mutation rewiring degron network	0.1111
p.A1733T	DO51605	CESC	ICGC	PRTPSCS	DEG_SCF_FBW7_1	1722:1728	Mutation rewiring degron network	0.1944
p.S1847L	TCGA-L5-A4OI	ESCA	TCGA	DRAPLPPVP	DEG_APCC_DBOX_1	1831:1839	Mutation blocking phosphorylation signal	0.5556
p.S1847L	TCGA-RU-A8FL	COAD	TCGA	DRAPLPPVP	DEG_APCC_DBOX_1	1831:1839	Mutation blocking phosphorylation signal	0.5556
p.S1847L	DO51733	COAD	ICGC	DRAPLPPVP	DEG_APCC_DBOX_1	1831:1839	Mutation blocking phosphorylation signal	0.5556
p.D891G	TCGA-UB-A7MB	LIHC	TCGA	DYR	CBL_MET	899:901	Mutation rewiring degron network	0.1111
p.D891G	DO52318	LIHC	ICGC	DYR	CBL_MET	899:901	Mutation rewiring degron network	0.1111
p.A874V	TCGA-UB-A7MC	LIHC	TCGA	DYR	CBL_MET	864:866	Mutation rewiring degron network	0.1111
p.A874V	DO52319	LIHC	ICGC	DYR	CBL_MET	864:866	Mutation rewiring degron network	0.1111
p.P1877S	TCGA-XK-AAIW	PRAD	TCGA	VTVTPSPE	DEG_SCF_FBW7_2	1873:1880	Mutation altering degron motif	0.6752
p.P1877S	DO51407	PRAD	ICGC	VTVTPSPE	DEG_SCF_FBW7_2	1873:1880	Mutation altering degron motif	0.6752
p.P861S	TCGA-XK-AAIW	PRAD	TCGA	DYR	CBL_MET	864:866	Mutation rewiring degron network	0.25
p.P861S	DO51407	PRAD	ICGC	DYR	CBL_MET	864:866	Mutation rewiring degron network	0.25
p.H1866P	DO48386	BLCA	ICGC	VTVTPSPE	DEG_SCF_FBW7_2	1873:1880	Mutation rewiring degron network	0.1389
p.P2059H	DO228483	BRCA	ICGC	AISTS	DEG_SPOP_SBC_1	2047:2051	Mutation rewiring degron network	0.1111
p.P2059H	DO229016	COCA	ICGC	AISTS	DEG_SPOP_SBC_1	2047:2051	Mutation rewiring degron network	0.1111
p.P1713T	DO222769	COCA	ICGC	PRTPSCS	DEG_SCF_FBW7_1	1722:1728	Mutation rewiring degron network	0.0833
p.R890Q	DO50372	ESAD	ICGC	DYR	CBL_MET	899:901	Mutation rewiring degron network	0.0833
p.R890Q	DO233833	GACA	ICGC	DYR	CBL_MET	899:901	Mutation rewiring degron network	0.0833
p.R890Q	SIDM00330	Neuroblastoma	GDSC	DYR	CBL_MET	899:901	Mutation rewiring degron network	0.0833
p.R890Q	ACH-001355	Neuroblastoma	CCLE	DYR	CBL_MET	899:901	Mutation rewiring degron network	0.0833
p.R890Q	LAN-6	autonomic ganglia	COSMIC	DYR	CBL_MET	899:901	Mutation rewiring degron network	0.0833
p.D899N	DO234468	ESAD	ICGC	DYR	CBL_MET	899:901	Mutation altering degron motif	0.6932
p.E1880K	DO233828	GACA	ICGC	VTVTPSPE	DEG_SCF_FBW7_2	1873:1880	Mutation altering degron motif	0.7022
p.S528R	DO228974	LICA	ICGC	ASSTS	DEG_SPOP_SBC_1	520:524	Mutation rewiring degron network	0.2222
p.P1869Q	DO228971	LICA	ICGC	VTVTPSPE	DEG_SCF_FBW7_2	1873:1880	Mutation rewiring degron network	0.2222
p.P1826T	DO229019	LICA	ICGC	DRAPLPPVP	DEG_APCC_DBOX_1	1831:1839	Mutation rewiring degron network	0.1944
p.T319K	DO229019	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	309:313	Mutation rewiring degron network	0.1667
p.T319K	DO229027	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	309:313	Mutation rewiring degron network	0.1667
p.D1863E	DO229015	LICA	ICGC	VTVTPSPE	DEG_SCF_FBW7_2	1873:1880	Mutation rewiring degron network	0.0556
p.P1749H	DO229028	LICA	ICGC	DSQHSTPVPTA	DEG_COP1_1	1741:1751	Mutation altering degron motif	0.7694
p.S1728R	DO229025	LICA	ICGC	PRTPSCS	DEG_SCF_FBW7_1	1722:1728	Mutation altering degron motif	0.7427
p.A309E	DO229041	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	309:313	Mutation altering degron motif	0.7701
p.P306Q	DO229041	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	309:313	Mutation rewiring degron network	0.25
p.P1877Q	DO229045	LICA	ICGC	VTVTPSPE	DEG_SCF_FBW7_2	1873:1880	Mutation altering degron motif	0.7035
p.G316S	DO229052	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	309:313	Mutation rewiring degron network	0.25
p.K786N	DO229058	LICA	ICGC	KEKIFKE	LIG_APCC_ABBAyCdc20_2	791:797	Mutation substituting flanking lysine	0.3056
p.D1731E	DO229006	LICA	ICGC	DSQHSTPVPTA	DEG_COP1_1	1741:1751	Mutation rewiring degron network	0.0556
p.D1731E	DO229006	LICA	ICGC	PRTPSCS	DEG_SCF_FBW7_1	1722:1728	Mutation rewiring degron network	0.25
p.D304E	DO229006	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	309:313	Mutation rewiring degron network	0.1944
p.V2044F	DO50865	LICA	ICGC	AISTS	DEG_SPOP_SBC_1	2047:2051	Mutation rewiring degron network	0.25
p.P1799L	DO228253	MALY	ICGC	IRRTPEEE	DEG_SCF_FBW7_2	1795:1802	Mutation altering degron motif	0.7582
p.S1828L	DO220906	MELA	ICGC	DRAPLPPVP	DEG_APCC_DBOX_1	1831:1839	Mutation rewiring degron network	0.25
p.S2049F	DO51494	PACA	ICGC	AISTS	DEG_SPOP_SBC_1	2047:2051	Mutation altering degron motif	0.7982
p.F795L	DO232224	PBCA	ICGC	KEKIFKE	LIG_APCC_ABBAyCdc20_2	791:797	Mutation altering degron motif	0.6981
p.R52M	DO229229	THCA	ICGC	LTKTPKLE	DEG_SCF_FBW7_2	36:43	Mutation rewiring degron network	0.0833
p.G2040V	DO229242	THCA	ICGC	AISTS	DEG_SPOP_SBC_1	2047:2051	Mutation rewiring degron network	0.1389
p.S300T	DO221100	WT	ICGC	APSSS	DEG_SPOP_SBC_1	309:313	Mutation rewiring degron network	0.0833
p.A2047T	SIDM02049	Pancreatic Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	2047:2051	Mutation altering degron motif	0.7139
p.D1731V	SIDM00683	Prostate Carcinoma	GDSC	DSQHSTPVPTA	DEG_COP1_1	1741:1751	Mutation rewiring degron network	0.0556
p.D1731V	SIDM00683	Prostate Carcinoma	GDSC	PRTPSCS	DEG_SCF_FBW7_1	1722:1728	Mutation rewiring degron network	0.25
p.D1731V	ACH-000977	lymph node	CCLE	DSQHSTPVPTA	DEG_COP1_1	1741:1751	Mutation rewiring degron network	0.0556
p.D1731V	ACH-000977	lymph node	CCLE	PRTPSCS	DEG_SCF_FBW7_1	1722:1728	Mutation rewiring degron network	0.25
p.D1731V	LNCaP-Clone-FGC	prostate	COSMIC	DSQHSTPVPTA	DEG_COP1_1	1741:1751	Mutation rewiring degron network	0.0556
p.D1731V	LNCaP-Clone-FGC	prostate	COSMIC	PRTPSCS	DEG_SCF_FBW7_1	1722:1728	Mutation rewiring degron network	0.25
p.D1831Y	SIDM00007	Other Solid Cancers	GDSC	DRAPLPPVP	DEG_APCC_DBOX_1	1831:1839	Mutation altering degron motif	0.6214
p.D1831Y	ACH-001550	Skin Cancer	CCLE	DRAPLPPVP	DEG_APCC_DBOX_1	1831:1839	Mutation altering degron motif	0.6214
p.D1831Y	MCC13	skin	COSMIC	DRAPLPPVP	DEG_APCC_DBOX_1	1831:1839	Mutation altering degron motif	0.6214
p.D1731G	SIDM00860	Head and Neck Carcinoma	GDSC	DSQHSTPVPTA	DEG_COP1_1	1741:1751	Mutation rewiring degron network	0.0556
p.D1731G	SIDM00860	Head and Neck Carcinoma	GDSC	PRTPSCS	DEG_SCF_FBW7_1	1722:1728	Mutation rewiring degron network	0.25
p.D1731G	ACH-000846	Head and Neck Cancer	CCLE	DSQHSTPVPTA	DEG_COP1_1	1741:1751	Mutation rewiring degron network	0.0556
p.D1731G	ACH-000846	Head and Neck Cancer	CCLE	PRTPSCS	DEG_SCF_FBW7_1	1722:1728	Mutation rewiring degron network	0.25
p.D1731G	FADU	upper aerodigestive tract	COSMIC	DSQHSTPVPTA	DEG_COP1_1	1741:1751	Mutation rewiring degron network	0.0556
p.D1731G	FADU	upper aerodigestive tract	COSMIC	PRTPSCS	DEG_SCF_FBW7_1	1722:1728	Mutation rewiring degron network	0.25
p.F1803L	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	IRRTPEEE	DEG_SCF_FBW7_2	1795:1802	Mutation rewiring degron network	0.3056
p.F1803L	ACH-000605	Esophageal Cancer	CCLE	IRRTPEEE	DEG_SCF_FBW7_2	1795:1802	Mutation rewiring degron network	0.3056
p.F1803L	TE-6	oesophagus	COSMIC	IRRTPEEE	DEG_SCF_FBW7_2	1795:1802	Mutation rewiring degron network	0.3056
p.M868T	SIDM00364	B-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	864:866	Mutation rewiring degron network	0.2778
p.M868T	ACH-002059	Leukemia	CCLE	DYR	CBL_MET	864:866	Mutation rewiring degron network	0.2778
p.M868T	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	864:866	Mutation rewiring degron network	0.2778
p.D32Y	SIDM00282	Colorectal Carcinoma	GDSC	LTKTPKLE	DEG_SCF_FBW7_2	36:43	Mutation rewiring degron network	0.2222
p.D32Y	ACH-000998	Colon/Colorectal Cancer	CCLE	LTKTPKLE	DEG_SCF_FBW7_2	36:43	Mutation rewiring degron network	0.2222
p.D32Y	CW-2	large intestine	COSMIC	LTKTPKLE	DEG_SCF_FBW7_2	36:43	Mutation rewiring degron network	0.2222
p.A305T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	APSSS	DEG_SPOP_SBC_1	309:313	Mutation rewiring degron network	0.2222
p.V2044I	SIDM00854	Burkitt's Lymphoma	GDSC	AISTS	DEG_SPOP_SBC_1	2047:2051	Mutation rewiring degron network	0.25
p.D46N	SIDM00878	Breast Carcinoma	GDSC	LTKTPKLE	DEG_SCF_FBW7_2	36:43	Mutation rewiring degron network	0.25
p.D1738G	SIDM00713	Mesothelioma	GDSC	DSQHSTPVPTA	DEG_COP1_1	1741:1751	Mutation rewiring degron network	0.25
p.D1738G	SIDM00713	Mesothelioma	GDSC	PRTPSCS	DEG_SCF_FBW7_1	1722:1728	Mutation rewiring degron network	0.0556
p.D1738G	ACH-000153	Lung Cancer	CCLE	DSQHSTPVPTA	DEG_COP1_1	1741:1751	Mutation rewiring degron network	0.25
p.D1738G	ACH-000153	Lung Cancer	CCLE	PRTPSCS	DEG_SCF_FBW7_1	1722:1728	Mutation rewiring degron network	0.0556
p.D1738G	NCI-H2052	pleura	COSMIC	DSQHSTPVPTA	DEG_COP1_1	1741:1751	Mutation rewiring degron network	0.25
p.D1738G	NCI-H2052	pleura	COSMIC	PRTPSCS	DEG_SCF_FBW7_1	1722:1728	Mutation rewiring degron network	0.0556
p.S2051L	SIDM00035	Thyroid Gland Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	2047:2051	Mutation altering degron motif	0.7667
p.S2051L	ACH-000037	Sarcoma	CCLE	AISTS	DEG_SPOP_SBC_1	2047:2051	Mutation altering degron motif	0.7667
p.S521A	SIDM01653	Non-Cancerous	GDSC	ASSTS	DEG_SPOP_SBC_1	520:524	Mutation altering degron motif	0.6477
p.S521A	SIDM00207	Glioblastoma	GDSC	ASSTS	DEG_SPOP_SBC_1	520:524	Mutation altering degron motif	0.6477
p.S521A	ACH-002230	Brain Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	520:524	Mutation altering degron motif	0.6477
p.S521A	ACH-002351	Non-Cancerous	CCLE	ASSTS	DEG_SPOP_SBC_1	520:524	Mutation altering degron motif	0.6477
p.K31E	SIDM00357	Small Cell Lung Carcinoma	GDSC	LTKTPKLE	DEG_SCF_FBW7_2	36:43	Mutation substituting flanking lysine	0.3056
p.K31E	ACH-002193	Lung Cancer	CCLE	LTKTPKLE	DEG_SCF_FBW7_2	36:43	Mutation substituting flanking lysine	0.3056
p.K31E	RERF-LC-FM	lung	COSMIC	LTKTPKLE	DEG_SCF_FBW7_2	36:43	Mutation substituting flanking lysine	0.3056
p.P1839S	SIDM00126	Melanoma	GDSC	DRAPLPPVP	DEG_APCC_DBOX_1	1831:1839	Mutation altering degron motif	0.5641
p.P1839S	ACH-002147	Skin Cancer	CCLE	DRAPLPPVP	DEG_APCC_DBOX_1	1831:1839	Mutation altering degron motif	0.5641
p.P1839S	K2	skin	COSMIC	DRAPLPPVP	DEG_APCC_DBOX_1	1831:1839	Mutation altering degron motif	0.5641
p.H526L	SIDM00379	Glioma	GDSC	ASSTS	DEG_SPOP_SBC_1	520:524	Mutation rewiring degron network	0.2778
p.H526L	SK-MG-1	central nervous system	COSMIC	ASSTS	DEG_SPOP_SBC_1	520:524	Mutation rewiring degron network	0.2778
p.H1744Y	SIDM00783	Colorectal Carcinoma	GDSC	DSQHSTPVPTA	DEG_COP1_1	1741:1751	Mutation altering degron motif	0.6118
p.H1744Y	ACH-000971	Colon/Colorectal Cancer	CCLE	DSQHSTPVPTA	DEG_COP1_1	1741:1751	Mutation altering degron motif	0.6118
p.H1744Y	HCT-116	large intestine	COSMIC	DSQHSTPVPTA	DEG_COP1_1	1741:1751	Mutation altering degron motif	0.6118
p.R866M	SIDM01608	Endometrial Carcinoma	GDSC	DYR	CBL_MET	864:866	Mutation altering degron motif	0.8632
p.R866M	ACH-000990	Endometrial/Uterine Cancer	CCLE	DYR	CBL_MET	864:866	Mutation altering degron motif	0.8632
p.S299N	SIDM00168	Head and Neck Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	309:313	Mutation rewiring degron network	0.0556
p.S299N	ACH-000549	Head and Neck Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	309:313	Mutation rewiring degron network	0.0556
p.S870N	SIDM01580	Melanoma	GDSC	DYR	CBL_MET	864:866	Mutation rewiring degron network	0.2222
p.S519F	ACH-000217	Liver Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	520:524	Mutation rewiring degron network	0.3056
p.A2046T	ACH-000994	Endometrial/Uterine Cancer	CCLE	AISTS	DEG_SPOP_SBC_1	2047:2051	Mutation rewiring degron network	0.3056
p.I794T	ACH-001030	Bone Cancer	CCLE	KEKIFKE	LIG_APCC_ABBAyCdc20_2	791:797	Mutation altering degron motif	0.7078
p.L802R	ACH-001561	Lung Cancer	CCLE	KEKIFKE	LIG_APCC_ABBAyCdc20_2	791:797	Mutation rewiring degron network	0.1944
p.A531V	ACH-002348	Non-Cancerous	CCLE	ASSTS	DEG_SPOP_SBC_1	520:524	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANKRD11

UniProt ID: Q6UB99

Entrez ID: 29123

Protein name: Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ANKRD11 in