DegronMD - Q6UB99(ANKRD11)

FUNCTION: Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}.

GO - Biological processes (BP): anatomical structure morphogenesis [GO:0009653]; face morphogenesis [GO:0060325]; odontogenesis of dentin-containing tooth [GO:0042475]; skeletal system morphogenesis [GO:0048705]

GO - Molecular function (MF):

GO - Cellular component (CC): cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R866M	SIDM01608	Endometrial Carcinoma	GDSC	DYR	CBL_MET	864:866	Mutation altering degron motif	0.8632
p.R866M	ACH-000990	Endometrial/Uterine Cancer	CCLE	DYR	CBL_MET	864:866	Mutation altering degron motif	0.8632
p.S2049F	DO51494	PACA	ICGC	AISTS	DEG_SPOP_SBC_1	2047:2051	Mutation altering degron motif	0.7982
p.A309E	DO229041	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	309:313	Mutation altering degron motif	0.7701
p.P1749H	DO229028	LICA	ICGC	DSQHSTPVPTA	DEG_COP1_1	1741:1751	Mutation altering degron motif	0.7694
p.S524L	TCGA-AN-A0AK	BRCA	TCGA	ASSTS	DEG_SPOP_SBC_1	520:524	Mutation altering degron motif	0.7667
p.S524L	DO1608	BRCA	ICGC	ASSTS	DEG_SPOP_SBC_1	520:524	Mutation altering degron motif	0.7667
p.S524L	ACH-000128	Brain Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	520:524	Mutation altering degron motif	0.7667
p.S2051L	SIDM00035	Thyroid Gland Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	2047:2051	Mutation altering degron motif	0.7667
p.S2051L	ACH-000037	Sarcoma	CCLE	AISTS	DEG_SPOP_SBC_1	2047:2051	Mutation altering degron motif	0.7667
p.P1799L	DO228253	MALY	ICGC	IRRTPEEE	DEG_SCF_FBW7_2	1795:1802	Mutation altering degron motif	0.7582
p.A1751G	TCGA-20-0991	OV	TCGA	DSQHSTPVPTA	DEG_COP1_1	1741:1751	Mutation altering degron motif	0.754
p.A1751G	DO31949	OV	ICGC	DSQHSTPVPTA	DEG_COP1_1	1741:1751	Mutation altering degron motif	0.754
p.S1728R	DO229025	LICA	ICGC	PRTPSCS	DEG_SCF_FBW7_1	1722:1728	Mutation altering degron motif	0.7427
p.A309T	TCGA-AX-A0J0	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	309:313	Mutation altering degron motif	0.7139
p.A309T	DO41133	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	309:313	Mutation altering degron motif	0.7139
p.A2047T	SIDM02049	Pancreatic Carcinoma	GDSC	AISTS	DEG_SPOP_SBC_1	2047:2051	Mutation altering degron motif	0.7139
p.I794T	ACH-001030	Bone Cancer	CCLE	KEKIFKE	LIG_APCC_ABBAyCdc20_2	791:797	Mutation altering degron motif	0.7078
p.P1877Q	DO229045	LICA	ICGC	VTVTPSPE	DEG_SCF_FBW7_2	1873:1880	Mutation altering degron motif	0.7035
p.E1880K	DO233828	GACA	ICGC	VTVTPSPE	DEG_SCF_FBW7_2	1873:1880	Mutation altering degron motif	0.7022

Showing 1 to 20 of 218 entries

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Kaplan plot for ANKRD11 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANKRD11

UniProt ID: Q6UB99

Entrez ID: 29123

Protein name: Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ANKRD11 in