IL27RA
UniProt ID: Q6UWB1
Entrez ID: 9466
Protein name: Interleukin-27 receptor subunit alpha (IL-27 receptor subunit alpha) (IL-27R subunit alpha) (IL-27R-alpha) (IL-27RA) (Cytokine receptor WSX-1) (Cytokine receptor-like 1) (Type I T-cell cytokine receptor) (TCCR) (ZcytoR1)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Receptor for IL27. Requires IL6ST/GP130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and CNTFR (PubMed:19386761). Involved in the regu...
FUNCTION: Receptor for IL27. Requires IL6ST/GP130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and CNTFR (PubMed:19386761). Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms. {ECO:0000269|PubMed:14764690, ECO:0000269|PubMed:19386761}.
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GO - Biological processes (BP):
cell surface receptor signaling pathway [GO:0007166]; cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-positive bacterium [GO:0050830]; immune response [GO:0006955]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of interleukin-6 producti...
cell surface receptor signaling pathway [GO:0007166]; cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-positive bacterium [GO:0050830]; immune response [GO:0006955]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of T cell extravasation [GO:2000408]; negative regulation of T-helper 17 type immune response [GO:2000317]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type 2 immune response [GO:0002829]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of interferon-gamma production [GO:0032729]; positive regulation of T-helper 1 type immune response [GO:0002827]; regulation of isotype switching to IgG isotypes [GO:0048302]
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GO - Molecular function (MF):
cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; interleukin-27 receptor activity [GO:0045509]; transmembrane signaling receptor activity [GO:0004888]...
cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; interleukin-27 receptor activity [GO:0045509]; transmembrane signaling receptor activity [GO:0004888]
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GO - Cellular component (CC):
external side of plasma membrane [GO:0009897]; integral component of plasma membrane [GO:0005887]; interleukin-12 receptor complex [GO:0042022]; interleukin-23 receptor complex [GO:0072536]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]...
external side of plasma membrane [GO:0009897]; integral component of plasma membrane [GO:0005887]; interleukin-12 receptor complex [GO:0042022]; interleukin-23 receptor complex [GO:0072536]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]
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IL27RA
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Kaplan plot for IL27RA in
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*NOTE: the Kaplan plots were collected from OncoLnc