DegronMD - Q6UWW9(TMEM207)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G134C	TCGA-50-6592	LUAD	TCGA	PPPY	ITCH	136:139	Mutation rewiring degron network	0.2778
p.G134C	DO23742	LUAD	ICGC	PPPY	ITCH	136:139	Mutation rewiring degron network	0.2778
p.G134A	TCGA-78-7155	LUAD	TCGA	PPPY	ITCH	136:139	Mutation rewiring degron network	0.2778
p.G134A	DO23590	LUAD	ICGC	PPPY	ITCH	136:139	Mutation rewiring degron network	0.2778
p.E140K	TCGA-YD-A9TB	SKCM	TCGA	PPPY	ITCH	136:139	Mutation rewiring degron network	0.3056
p.E140K	DO51297	SKCM	ICGC	PPPY	ITCH	136:139	Mutation rewiring degron network	0.3056
p.T145K	DO229036	LICA	ICGC	PPPY	ITCH	136:139	Mutation rewiring degron network	0.1667
p.T145K	DO229037	LICA	ICGC	PPPY	ITCH	136:139	Mutation rewiring degron network	0.1667
p.A127S	DO231361	THCA	ICGC	PPPY	ITCH	136:139	Mutation rewiring degron network	0.0833
p.F130V	SIDM00426	Rhabdomyosarcoma	GDSC	PPPY	ITCH	136:139	Mutation rewiring degron network	0.1667
p.F130V	ACH-000100	Sarcoma	CCLE	PPPY	ITCH	136:139	Mutation rewiring degron network	0.1667
p.F130V	ACH-001765	Sarcoma	CCLE	PPPY	ITCH	136:139	Mutation rewiring degron network	0.1667
p.F130V	RH-41	soft tissue	COSMIC	PPPY	ITCH	136:139	Mutation rewiring degron network	0.1667
p.G131R	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	136:139	Mutation rewiring degron network	0.1944
p.G131R	ACH-000860	Lung Cancer	CCLE	PPPY	ITCH	136:139	Mutation rewiring degron network	0.1944
p.G131R	NCI-H358	lung	COSMIC	PPPY	ITCH	136:139	Mutation rewiring degron network	0.1944
p.E140D	ACH-001148	Lymphoma	CCLE	PPPY	ITCH	136:139	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons