DegronMD - Q6UXN2(TREML4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P142S	TCGA-3N-A9WC	SKCM	TCGA	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.1667
p.P142S	DO51234	SKCM	ICGC	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.1667
p.L122I	TCGA-AX-A05Z	UCEC	TCGA	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.0556
p.L122I	DO40884	UCEC	ICGC	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.0556
p.P137L	TCGA-D3-A8GI	SKCM	TCGA	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.3056
p.P137L	DO50284	SKCM	ICGC	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.3056
p.T134S	TCGA-DX-A6BK	SARC	TCGA	APTTS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.6005
p.T134S	DO220001	SARC	ICGC	APTTS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.6005
p.P131Q	TCGA-ED-A8O5	LIHC	TCGA	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.3056
p.P131Q	DO48558	LIHC	ICGC	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.3056
p.L141I	TCGA-FI-A2D5	UCEC	TCGA	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.1944
p.L141I	DO41331	UCEC	ICGC	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.1944
p.L122F	TCGA-FR-A726	SKCM	TCGA	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.0556
p.L122F	DO48665	SKCM	ICGC	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.0556
p.L122F	SIDM00861	Ovarian Carcinoma	GDSC	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.0556
p.L122F	ACH-000906	Ovarian Cancer	CCLE	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.0556
p.L122F	ES-2	ovary	COSMIC	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.0556
p.P145S	TCGA-FS-A1ZC	SKCM	TCGA	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.0833
p.P145S	DO37487	SKCM	ICGC	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.0833
p.P137S	TCGA-W3-AA21	SKCM	TCGA	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.3056
p.P137S	DO51278	SKCM	ICGC	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.3056
p.P137S	SIDM00007	Other Solid Cancers	GDSC	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.3056
p.P137S	ACH-001550	Skin Cancer	CCLE	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.3056
p.P137S	MCC13	skin	COSMIC	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.3056
p.P142L	DO220902	MELA	ICGC	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.1667
p.P133T	DO35242	PACA	ICGC	APTTS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.5919
p.T135M	DO51057	PRAD	ICGC	APTTS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.7423
p.T135M	SIDM00549	B-Lymphoblastic Leukemia	GDSC	APTTS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.7423
p.S136C	DO46957	RECA	ICGC	APTTS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.7541
p.S136C	SIDM01042	Breast Carcinoma	GDSC	APTTS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.7541
p.S136C	ACH-001065	Breast Cancer	CCLE	APTTS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.7541
p.S136C	EVSA-T	breast	COSMIC	APTTS	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.7541
p.T146K	SIDM00454	Rhabdomyosarcoma	GDSC	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.0556
p.T146K	SIDM00346	Chronic Myelogenous Leukemia	GDSC	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.0556
p.T146K	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.0556
p.T146K	SIDM00849	Kidney Carcinoma	GDSC	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.0556
p.T146K	SIDM00032	Bladder Carcinoma	GDSC	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.0556
p.T146K	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.0556
p.T146K	SIDM00954	Breast Carcinoma	GDSC	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.0556
p.T146K	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.0556
p.T146K	SIDM00257	Neuroblastoma	GDSC	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.0556
p.T146K	SIDM00673	Breast Carcinoma	GDSC	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.0556
p.T146K	SIDM00808	Burkitt's Lymphoma	GDSC	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.0556
p.T146K	SIDM00628	Breast Carcinoma	GDSC	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.0556
p.T146K	SIDM01475	Ovarian Carcinoma	GDSC	APTTS	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TREML4

UniProt ID: Q6UXN2

Entrez ID: 285852

Protein name: Trem-like transcript 4 protein (TLT-4) (Triggering receptor expressed on myeloid cells-like protein 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TREML4 in