DegronMD - Q6VN20(RANBP10)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S420T	TCGA-97-8179	LUAD	TCGA	APSSS	DEG_SPOP_SBC_1	407:411	Mutation blocking phosphorylation signal	0.5278
p.S417F	TCGA-D3-A1Q5	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.1667
p.S416F	TCGA-D6-6516	HNSC	TCGA	APSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.1944
p.S415F	TCGA-EE-A29M	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	407:411	Mutation blocking phosphorylation signal	0.6667
p.H402N	TCGA-FS-A1ZN	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.1944
p.P408S	TCGA-YD-A9TA	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	407:411	Mutation altering degron motif	0.5641
p.P416T	DO38675	STAD	ICGC	APSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.1944
p.A409V	DO47912	STAD	ICGC	APSSS	DEG_SPOP_SBC_1	407:411	Mutation altering degron motif	0.6936
p.S414F	SIDM01006	Plasma Cell Myeloma	GDSC	APSSS	DEG_SPOP_SBC_1	407:411	Mutation blocking phosphorylation signal	0.6944
p.S414F	ACH-000193	Myeloma	CCLE	APSSS	DEG_SPOP_SBC_1	407:411	Mutation blocking phosphorylation signal	0.6944
p.S419L	SIDM00817	Kidney Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	407:411	Mutation blocking phosphorylation signal	0.5556
p.S419L	SIDM01160	Bladder Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	407:411	Mutation blocking phosphorylation signal	0.5556
p.Q400E	ACH-000262	Kidney Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.1389

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons