DegronMD - Q6X4W1(NSMF)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R196H	TCGA-06-0648	GBM	TCGA	RRKKLERMY	DEG_APCC_DBOX_1	195:203	Mutation altering degron motif	0.8244
p.R196H	DO11022	GBM	ICGC	RRKKLERMY	DEG_APCC_DBOX_1	195:203	Mutation altering degron motif	0.8244
p.A174V	TCGA-22-4599	LUSC	TCGA	LAPGPTPRAFGL	DEG_ODPH_VHL_1	173:184	Mutation altering degron motif	0.6936
p.A174V	DO26945	LUSC	ICGC	LAPGPTPRAFGL	DEG_ODPH_VHL_1	173:184	Mutation altering degron motif	0.6936
p.S308I	TCGA-33-6738	LUSC	TCGA	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	291:298	Mutation rewiring degron network	0.0556
p.P177T	TCGA-56-8626	LUSC	TCGA	LAPGPTPRAFGL	DEG_ODPH_VHL_1	173:184	Mutation altering degron motif	0.5919
p.P177T	DO45506	LUSC	ICGC	LAPGPTPRAFGL	DEG_ODPH_VHL_1	173:184	Mutation altering degron motif	0.5919
p.R201S	TCGA-58-8386	LUSC	TCGA	RRKKLERMY	DEG_APCC_DBOX_1	195:203	Mutation altering degron motif	0.6316
p.R201S	DO45537	LUSC	ICGC	RRKKLERMY	DEG_APCC_DBOX_1	195:203	Mutation altering degron motif	0.6316
p.P179H	TCGA-AP-A059	UCEC	TCGA	LAPGPTPRAFGL	DEG_ODPH_VHL_1	173:184	Mutation altering degron motif	0.6583
p.P179H	DO41361	UCEC	ICGC	LAPGPTPRAFGL	DEG_ODPH_VHL_1	173:184	Mutation altering degron motif	0.6583
p.R180W	TCGA-AP-A1DV	UCEC	TCGA	LAPGPTPRAFGL	DEG_ODPH_VHL_1	173:184	Mutation altering degron motif	0.7523
p.R180W	DO43186	UCEC	ICGC	LAPGPTPRAFGL	DEG_ODPH_VHL_1	173:184	Mutation altering degron motif	0.7523
p.R207C	TCGA-B5-A3FC	UCEC	TCGA	RRKKLERMY	DEG_APCC_DBOX_1	195:203	Mutation rewiring degron network	0.2222
p.R207C	DO41871	UCEC	ICGC	RRKKLERMY	DEG_APCC_DBOX_1	195:203	Mutation rewiring degron network	0.2222
p.R289Q	TCGA-BR-4362	STAD	TCGA	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	291:298	Mutation rewiring degron network	0.2778
p.A276T	TCGA-D1-A103	UCEC	TCGA	FRKHLRMVG	DEG_APCC_DBOX_1	262:270	Mutation rewiring degron network	0.1667
p.Q277H	TCGA-EK-A2R8	CESC	TCGA	FRKHLRMVG	DEG_APCC_DBOX_1	262:270	Mutation rewiring degron network	0.1389
p.R180G	TCGA-FD-A6TC	BLCA	TCGA	LAPGPTPRAFGL	DEG_ODPH_VHL_1	173:184	Mutation altering degron motif	0.6457
p.R180G	DO49755	BLCA	ICGC	LAPGPTPRAFGL	DEG_ODPH_VHL_1	173:184	Mutation altering degron motif	0.6457
p.D304G	TCGA-FI-A2D5	UCEC	TCGA	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	291:298	Mutation rewiring degron network	0.1667
p.R195H	TCGA-FI-A2D5	UCEC	TCGA	RRKKLERMY	DEG_APCC_DBOX_1	195:203	Mutation altering degron motif	0.7133
p.R195H	DO41331	UCEC	ICGC	RRKKLERMY	DEG_APCC_DBOX_1	195:203	Mutation altering degron motif	0.7133
p.M258V	DO219018	BLCA	ICGC	FRKHLRMVG	DEG_APCC_DBOX_1	262:270	Mutation rewiring degron network	0.2222
p.I255N	DO222769	COCA	ICGC	FRKHLRMVG	DEG_APCC_DBOX_1	262:270	Mutation rewiring degron network	0.1389
p.E307Q	DO233925	GACA	ICGC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	291:298	Mutation rewiring degron network	0.0833
p.G198A	DO15238	HNSC	ICGC	RRKKLERMY	DEG_APCC_DBOX_1	195:203	Mutation altering degron motif	0.754
p.N193H	DO223831	KIRC	ICGC	RRKKLERMY	DEG_APCC_DBOX_1	195:203	Mutation rewiring degron network	0.2778
p.N193H	DO223831	KIRC	ICGC	LAPGPTPRAFGL	DEG_ODPH_VHL_1	173:184	Mutation rewiring degron network	0.0833
p.W304C	DO20917	KIRP	ICGC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	291:298	Mutation rewiring degron network	0.1667
p.S204R	DO229031	LICA	ICGC	RRKKLERMY	DEG_APCC_DBOX_1	195:203	Mutation blocking phosphorylation signal	0.75
p.C260Y	DO50835	LICA	ICGC	FRKHLRMVG	DEG_APCC_DBOX_1	262:270	Mutation rewiring degron network	0.2778
p.A179T	DO219357	PRAD	ICGC	LAPGPTPRAFGL	DEG_ODPH_VHL_1	173:184	Mutation altering degron motif	0.7139
p.P281L	DO37406	SKCM	ICGC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	291:298	Mutation rewiring degron network	0.0556
p.R163C	DO48665	SKCM	ICGC	LAPGPTPRAFGL	DEG_ODPH_VHL_1	173:184	Mutation rewiring degron network	0.0556
p.E182K	DO38495	STAD	ICGC	LAPGPTPRAFGL	DEG_ODPH_VHL_1	173:184	Mutation altering degron motif	0.7022
p.E182K	DO43907	UCEC	ICGC	LAPGPTPRAFGL	DEG_ODPH_VHL_1	173:184	Mutation altering degron motif	0.7022
p.H256N	DO51776	STAD	ICGC	FRKHLRMVG	DEG_APCC_DBOX_1	262:270	Mutation rewiring degron network	0.1667
p.L302P	DO47957	STAD	ICGC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	291:298	Mutation blocking phosphorylation signal	0.6667
p.R266Q	DO38336	STAD	ICGC	FRKHLRMVG	DEG_APCC_DBOX_1	262:270	Mutation altering degron motif	0.7329
p.S285N	DO229232	THCA	ICGC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	291:298	Mutation rewiring degron network	0.1667
p.P171T	DO223282	UCEC	ICGC	LAPGPTPRAFGL	DEG_ODPH_VHL_1	173:184	Mutation rewiring degron network	0.2778
p.V254I	DO41784	UCEC	ICGC	FRKHLRMVG	DEG_APCC_DBOX_1	262:270	Mutation rewiring degron network	0.1111
p.R289W	SIDM00389	B-Cell Non-Hodgkin's Lymphoma	GDSC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	291:298	Mutation rewiring degron network	0.2778
p.R289W	SU-DHL-10	haematopoietic and lymphoid tissue	COSMIC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	291:298	Mutation rewiring degron network	0.2778
p.V205I	SIDM00997	Thyroid Gland Carcinoma	GDSC	RRKKLERMY	DEG_APCC_DBOX_1	195:203	Mutation rewiring degron network	0.2778
p.V205I	ACH-001306	Thyroid Cancer	CCLE	RRKKLERMY	DEG_APCC_DBOX_1	195:203	Mutation rewiring degron network	0.2778
p.V205I	8305C	thyroid	COSMIC	RRKKLERMY	DEG_APCC_DBOX_1	195:203	Mutation rewiring degron network	0.2778
p.A255V	SIDM00118	Colorectal Carcinoma	GDSC	FRKHLRMVG	DEG_APCC_DBOX_1	262:270	Mutation rewiring degron network	0.1389
p.A255V	HCC2998	large intestine	COSMIC	FRKHLRMVG	DEG_APCC_DBOX_1	262:270	Mutation rewiring degron network	0.1389
p.R287W	ACH-000271	Lymphoma	CCLE	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	291:298	Mutation rewiring degron network	0.2222
p.R287W	SU-DHL-10	haematopoietic and lymphoid tissue	COSMIC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	291:298	Mutation rewiring degron network	0.2222
p.A253V	ACH-001081	Colon/Colorectal Cancer	CCLE	FRKHLRMVG	DEG_APCC_DBOX_1	262:270	Mutation rewiring degron network	0.0833
p.A253V	HCC2998	large intestine	COSMIC	FRKHLRMVG	DEG_APCC_DBOX_1	262:270	Mutation rewiring degron network	0.0833
p.T295P	HCC-366	lung	COSMIC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	291:298	Mutation altering degron motif	0.7031
p.T287M	786-0	kidney	COSMIC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	291:298	Mutation rewiring degron network	0.2222
p.E295K	SNU-1040	large intestine	COSMIC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	291:298	Mutation altering degron motif	0.7022
p.T270P	HCC-366	lung	COSMIC	FRKHLRMVG	DEG_APCC_DBOX_1	262:270	Mutation altering degron motif	0.7031
p.R266W	SU-DHL-10	haematopoietic and lymphoid tissue	COSMIC	FRKHLRMVG	DEG_APCC_DBOX_1	262:270	Mutation altering degron motif	0.8634
p.T293P	HCC-366	lung	COSMIC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	291:298	Mutation altering degron motif	0.7031
p.T294M	786-0	kidney	COSMIC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	291:298	Mutation altering degron motif	0.7423
p.E297K	SNU-1040	large intestine	COSMIC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	291:298	Mutation altering degron motif	0.7022
p.E290K	SNU-1040	large intestine	COSMIC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	291:298	Mutation rewiring degron network	0.3056
p.T272P	HCC-366	lung	COSMIC	FRKHLRMVG	DEG_APCC_DBOX_1	262:270	Mutation rewiring degron network	0.2778
p.T292M	786-0	kidney	COSMIC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	291:298	Mutation altering degron motif	0.7423
p.R264W	SU-DHL-10	haematopoietic and lymphoid tissue	COSMIC	FRKHLRMVG	DEG_APCC_DBOX_1	262:270	Mutation altering degron motif	0.8634

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NSMF

UniProt ID: Q6X4W1

Entrez ID: 26012

Protein name: NMDA receptor synaptonuclear signaling and neuronal migration factor (Nasal embryonic luteinizing hormone-releasing hormone factor) (Nasal embryonic LHRH factor)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for NSMF in