DegronMD - Q6X4W1(NSMF)

FUNCTION: Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells. {ECO:0000269|PubMed:20025934}.

GO - Biological processes (BP): cellular response to amino acid stimulus [GO:0071230]; cellular response to electrical stimulus [GO:0071257]; cellular response to gonadotropin stimulus [GO:0071371]; positive regulation of neuron migration [GO:2001224]; positive regulation of protein dephosphorylation [GO:0035307]; regulation of de... View more >>

GO - Molecular function (MF): calcium-dependent protein binding [GO:0048306]

GO - Cellular component (CC): apical dendrite [GO:0097440]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; euchromatin [GO:0000791]; membrane [GO:0016020]; neuron projection [GO:0043005]; nuclear envelope [GO:0005635]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nucleoplasm [GO... View more >>

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
RRKKLERMY	DEG_APCC_DBOX_1	APC,CDC20,FZR1	NMDA receptor synaptonuclear signaling and neuronal migration factor	195:203	More..
FRKHLRMVG	DEG_APCC_DBOX_1	APC,CDC20,FZR1	NMDA receptor synaptonuclear signaling and neuronal migration factor	262:270	More..
LAPGPTPRAFGL	DEG_ODPH_VHL_1	VHL	NMDA receptor synaptonuclear signaling and neuronal migration factor	173:184	More..
WSDPTPMK	DEG_SCF_SKP2-CKS1_1	SKP2,CSK1	NMDA receptor synaptonuclear signaling and neuronal migration factor	291:298	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R266W	SU-DHL-10	haematopoietic and lymphoid tissue	COSMIC	FRKHLRMVG	DEG_APCC_DBOX_1	262:270	Mutation altering degron motif	0.8634
p.R264W	SU-DHL-10	haematopoietic and lymphoid tissue	COSMIC	FRKHLRMVG	DEG_APCC_DBOX_1	262:270	Mutation altering degron motif	0.8634
p.R196H	TCGA-06-0648	GBM	TCGA	RRKKLERMY	DEG_APCC_DBOX_1	195:203	Mutation altering degron motif	0.8244
p.R196H	DO11022	GBM	ICGC	RRKKLERMY	DEG_APCC_DBOX_1	195:203	Mutation altering degron motif	0.8244
p.G198A	DO15238	HNSC	ICGC	RRKKLERMY	DEG_APCC_DBOX_1	195:203	Mutation altering degron motif	0.754
p.R180W	TCGA-AP-A1DV	UCEC	TCGA	LAPGPTPRAFGL	DEG_ODPH_VHL_1	173:184	Mutation altering degron motif	0.7523
p.R180W	DO43186	UCEC	ICGC	LAPGPTPRAFGL	DEG_ODPH_VHL_1	173:184	Mutation altering degron motif	0.7523
p.S204R	DO229031	LICA	ICGC	RRKKLERMY	DEG_APCC_DBOX_1	195:203	Mutation blocking phosphorylation signal	0.75
p.T294M	786-0	kidney	COSMIC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	291:298	Mutation altering degron motif	0.7423
p.T292M	786-0	kidney	COSMIC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	291:298	Mutation altering degron motif	0.7423
p.R266Q	DO38336	STAD	ICGC	FRKHLRMVG	DEG_APCC_DBOX_1	262:270	Mutation altering degron motif	0.7329
p.A179T	DO219357	PRAD	ICGC	LAPGPTPRAFGL	DEG_ODPH_VHL_1	173:184	Mutation altering degron motif	0.7139
p.R195H	TCGA-FI-A2D5	UCEC	TCGA	RRKKLERMY	DEG_APCC_DBOX_1	195:203	Mutation altering degron motif	0.7133
p.R195H	DO41331	UCEC	ICGC	RRKKLERMY	DEG_APCC_DBOX_1	195:203	Mutation altering degron motif	0.7133
p.T295P	HCC-366	lung	COSMIC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	291:298	Mutation altering degron motif	0.7031
p.T270P	HCC-366	lung	COSMIC	FRKHLRMVG	DEG_APCC_DBOX_1	262:270	Mutation altering degron motif	0.7031
p.T293P	HCC-366	lung	COSMIC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	291:298	Mutation altering degron motif	0.7031
p.E182K	DO38495	STAD	ICGC	LAPGPTPRAFGL	DEG_ODPH_VHL_1	173:184	Mutation altering degron motif	0.7022
p.E182K	DO43907	UCEC	ICGC	LAPGPTPRAFGL	DEG_ODPH_VHL_1	173:184	Mutation altering degron motif	0.7022
p.E295K	SNU-1040	large intestine	COSMIC	WSDPTPMK	DEG_SCF_SKP2-CKS1_1	291:298	Mutation altering degron motif	0.7022

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

NSMF

UniProt ID: Q6X4W1

Entrez ID: 26012

Protein name: NMDA receptor synaptonuclear signaling and neuronal migration factor (Nasal embryonic luteinizing hormone-releasing hormone factor) (Nasal embryonic LHRH factor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NSMF in