DegronMD - Q6ZQX7(LIAT1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I121F	TCGA-AN-A0XN	BRCA	TCGA	PLSSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.2222
p.I121F	DO3745	BRCA	ICGC	PLSSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.2222
p.P113L	TCGA-EY-A1GO	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	113:117	Mutation altering degron motif	0.7582
p.P113L	DO41392	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	113:117	Mutation altering degron motif	0.7582
p.P124T	TCGA-IB-7651	PAAD	TCGA	PLSSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.1389
p.P124T	DO46657	PAAD	ICGC	PLSSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.1389
p.P124L	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PLSSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.1389
p.P124L	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PLSSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.1389
p.P124L	ACH-000995	Leukemia	CCLE	PLSSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.1389
p.F118S	SIDM01608	Endometrial Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.3056
p.F118S	ACH-000990	Endometrial/Uterine Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.3056
p.P123L	ACH-000956	Prostate Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	113:117	Mutation blocking phosphorylation signal	0.6111

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons