DegronMD - Q6ZU80(CEP128)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A2T	TCGA-A5-A0G2	UCEC	TCGA	AESSS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.7139
p.A2T	DO41235	UCEC	ICGC	AESSS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.7139
p.A2E	TCGA-B7-5816	STAD	TCGA	AESSS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.7701
p.A2E	DO38599	STAD	ICGC	AESSS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.7701
p.C13Y	TCGA-CD-A486	STAD	TCGA	AESSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1389
p.C13Y	DO47853	STAD	ICGC	AESSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1389
p.E7K	TCGA-EI-6917	READ	TCGA	AESSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.3056
p.E7K	DO36881	READ	ICGC	AESSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.3056
p.R16L	DO229016	COCA	ICGC	AESSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.0556
p.R16Q	SIDM00773	Non-Cancerous	GDSC	AESSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.0556
p.R16Q	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.0556
p.R16Q	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.0556
p.R16Q	SIDM01147	Gastric Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.0556
p.R16Q	HCE-4	oesophagus	COSMIC	AESSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.0556
p.R16Q	NCI-N87	stomach	COSMIC	AESSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.0556
p.R16Q	EMC-BAC-1	lung	COSMIC	AESSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.0556
p.E7V	SIDM00135	Breast Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.3056
p.E7V	ACH-000148	Breast Cancer	CCLE	AESSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.3056
p.E7V	Hs-578-T	breast	COSMIC	AESSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.3056
p.R14H	SIDM00364	B-Lymphoblastic Leukemia	GDSC	AESSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1111
p.R14H	SIDM01473	Plasma Cell Myeloma	GDSC	AESSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1111
p.R14H	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	AESSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1111

Kaplan plot for CEP128 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CEP128

UniProt ID: Q6ZU80

Entrez ID: 145508

Protein name: Centrosomal protein of 128 kDa (Cep128)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CEP128 in