DegronMD - Q6ZV89(SH2D5)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T164R	TCGA-37-5819	LUSC	TCGA	PLSSS	DEG_SPOP_SBC_1	171:175	Mutation blocking phosphorylation signal	0.5833
p.E181K	TCGA-CV-7099	HNSC	TCGA	PLSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.1667
p.R162C	DO51646	CESC	ICGC	PLSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.0833
p.R167H	DO8778	COAD	ICGC	PLSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.2222
p.E172G	DO233179	GACA	ICGC	PLSSS	DEG_SPOP_SBC_1	171:175	Mutation altering degron motif	0.7199
p.Q176K	DO228974	LICA	ICGC	PLSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.3056
p.G164R	DO52194	LIHC	ICGC	PLSSS	DEG_SPOP_SBC_1	171:175	Mutation blocking phosphorylation signal	0.5833
p.E181D	DO45422	LUAD	ICGC	PLSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.1667
p.G168S	DO29708	OV	ICGC	PLSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.25
p.G168S	DO51965	PRAD	ICGC	PLSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.25
p.R162H	DO50258	PAAD	ICGC	PLSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.0833
p.R162H	SNU-407	large intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.0833
p.P184S	DO37446	SKCM	ICGC	PLSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.0833
p.P184L	DO37446	SKCM	ICGC	PLSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.0833
p.Y166H	DO48547	STAD	ICGC	PLSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.1944
p.G177D	SIDM00155	Head and Neck Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.2778
p.G177D	ACH-002296	Head and Neck Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.2778
p.G177D	PCI-38	upper aerodigestive tract	COSMIC	PLSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.2778
p.G184A	SIDM00792	Small Cell Lung Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.0833
p.G184A	ACH-002170	Lung Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.0833
p.G184A	NCI-H1688	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.0833
p.S173P	SIDM01611	Endometrial Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	171:175	Mutation altering degron motif	0.6752
p.S173P	ACH-000996	Endometrial/Uterine Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	171:175	Mutation altering degron motif	0.6752
p.R180Q	SIDM01451	Pancreatic Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.1944
p.R180Q	ACH-000933	Pancreatic Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.1944
p.V167G	ACH-000050	Myeloma	CCLE	PLSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.2222
p.V167G	NCI-H929	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.2222
p.R167C	SW948	large intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.2222
p.R167S	NCI-H358	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SH2D5

UniProt ID: Q6ZV89

Entrez ID: 400745

Protein name: SH2 domain-containing protein 5

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SH2D5 in