DegronMD - Q6ZWB6(KCTD8)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G10D	TCGA-CD-A4MG	STAD	TCGA	VSSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.0556
p.G10D	DO48009	STAD	ICGC	VSSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.0556
p.A28V	TCGA-CD-A4MJ	STAD	TCGA	VSSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.2222
p.A28V	DO47811	STAD	ICGC	VSSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.2222
p.A28V	SIDM00431	T-Lymphoblastic Leukemia	GDSC	VSSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.2222
p.A28V	ACH-000918	Leukemia	CCLE	VSSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.2222
p.A28V	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.2222
p.A30T	TCGA-EJ-7782	PRAD	TCGA	VSSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1667
p.A30T	DO36256	PRAD	ICGC	VSSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1667
p.S25L	DO234393	ESAD	ICGC	VSSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.3056
p.S22L	DO227727	PACA	ICGC	VSSSS	DEG_SPOP_SBC_1	20:24	Mutation altering degron motif	0.7667
p.A33S	SIDM00985	Burkitt's Lymphoma	GDSC	VSSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.0833
p.A33S	ACH-000245	Lymphoma	CCLE	VSSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.0833
p.A33S	BL-41	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.0833
p.P34R	SIDM00216	Colorectal Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.0556
p.P34R	ACH-000989	Colon/Colorectal Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.0556
p.P34R	SNU-175	large intestine	COSMIC	VSSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.0556
p.A31G	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	VSSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1389
p.A31G	SIDM00281	Other Solid Cancers	GDSC	VSSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1389
p.A31G	SIDM00243	Other Solid Cancers	GDSC	VSSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1389
p.A31G	ACH-000697	Lymphoma	CCLE	VSSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1389
p.A31G	ACH-002100	Skin Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1389
p.A31G	ACH-002288	Embryonal Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1389
p.A31G	NEC8	testis	COSMIC	VSSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1389
p.A31G	A3-KAW	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1389
p.A31G	DJM-1	skin	COSMIC	VSSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1389
p.A32S	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1111
p.A32S	ACH-000843	Lung Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1111
p.A32S	HARA	lung	COSMIC	VSSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1111
p.A33T	SIDM00927	Small Cell Lung Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.0833
p.A33T	ACH-000871	Lung Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.0833
p.A33T	NCI-H510A	lung	COSMIC	VSSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.0833
p.A32T	ACH-000937	Leukemia	CCLE	VSSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1111

Kaplan plot for KCTD8 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KCTD8

UniProt ID: Q6ZWB6

Entrez ID: 386617

Protein name: BTB/POZ domain-containing protein KCTD8

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for KCTD8 in