DegronMD - Q6ZWK6(TMPRSS11F)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q208K	TCGA-09-2044	OV	TCGA	PASSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.1667
p.Q208K	DO28923	OV	ICGC	PASSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.1667
p.V207A	TCGA-56-8083	LUSC	TCGA	PASSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.1944
p.V207A	DO223723	LUSC	ICGC	PASSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.1944
p.I206T	TCGA-A3-3331	KIRC	TCGA	PASSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.2222
p.R205I	TCGA-AG-3892	READ	TCGA	PASSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.25
p.R205I	TCGA-CA-6718	COAD	TCGA	PASSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.25
p.R205I	TCGA-D1-A103	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.25
p.R205I	DO7801	COAD	ICGC	PASSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.25
p.R205I	DO36394	READ	ICGC	PASSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.25
p.R205I	DO42312	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.25
p.R205I	SIDM00118	Colorectal Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.25
p.R205I	ACH-001081	Colon/Colorectal Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.25
p.R205I	HCC2998	large intestine	COSMIC	PASSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.25
p.E211K	TCGA-EO-A3AV	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.0833
p.E211K	DO52412	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.0833
p.G209R	TCGA-FS-A1Z3	SKCM	TCGA	PASSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.1389
p.G209R	DO37635	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.1389
p.R205T	TCGA-K4-A54R	BLCA	TCGA	PASSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.25
p.R205T	DO48611	BLCA	ICGC	PASSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.25
p.R210S	TCGA-P4-AAVL	KIRP	TCGA	PASSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.1111
p.R210S	DO219694	KIRP	ICGC	PASSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.1111
p.S192C	DO225215	BRCA	ICGC	PASSS	DEG_SPOP_SBC_1	198:202	Mutation blocking phosphorylation signal	0.6111
p.S192C	DO227836	BRCA	ICGC	PASSS	DEG_SPOP_SBC_1	198:202	Mutation blocking phosphorylation signal	0.6111
p.N194S	DO1127	BRCA	ICGC	PASSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.2222
p.V207D	DO44832	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.1944
p.G209E	DO222837	MELA	ICGC	PASSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.1389
p.M190I	SIDM01036	Plasma Cell Myeloma	GDSC	PASSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.1111
p.M190I	ACH-000653	Myeloma	CCLE	PASSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.1111
p.M190I	JJN-3	haematopoietic and lymphoid tissue	COSMIC	PASSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.1111
p.R210K	SIDM00129	Melanoma	GDSC	PASSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.1111
p.R210K	SIDM00855	Other Sarcomas	GDSC	PASSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.1111
p.R210K	SIDM00632	Non-Cancerous	GDSC	PASSS	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.1111
p.S202Y	SIDM00654	Small Cell Lung Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	198:202	Mutation altering degron motif	0.712

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMPRSS11F

UniProt ID: Q6ZWK6

Entrez ID: 389208

Protein name: Transmembrane protease serine 11F (EC 3.4.21.-) (Airway trypsin-like protease 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMPRSS11F in