DegronMD - Q709C8(VPS13C)

VPS13C

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A301T	TCGA-EY-A2OP	UCEC	TCGA	PPNY	ITCH	289:292	Mutation rewiring degron network	0.0833
p.P289H	TCGA-HU-A4GQ	STAD	TCGA	PPNY	ITCH	289:292	Mutation altering degron motif	0.7694
p.I281V	DO233116	GACA	ICGC	PPNY	ITCH	289:292	Mutation rewiring degron network	0.1111
p.C279F	DO22427	LGG	ICGC	PPNY	ITCH	289:292	Mutation substituting flanking lysine	0.1667
p.N280K	DO229018	LICA	ICGC	PPNY	ITCH	289:292	Mutation rewiring degron network	0.0833
p.N280K	DO229041	LICA	ICGC	PPNY	ITCH	289:292	Mutation rewiring degron network	0.0833
p.P293S	DO229177	LMS	ICGC	PPNY	ITCH	289:292	Mutation rewiring degron network	0.3056
p.M298I	DO45510	LUSC	ICGC	PPNY	ITCH	289:292	Mutation rewiring degron network	0.1667
p.N285I	DO222875	MELA	ICGC	PPNY	ITCH	289:292	Mutation rewiring degron network	0.2222
p.Q294E	DO51741	STAD	ICGC	PPNY	ITCH	289:292	Mutation rewiring degron network	0.2778
p.E281K	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	PPNY	ITCH	289:292	Mutation rewiring degron network	0.1111
p.E281K	ACH-000951	Lung Cancer	CCLE	PPNY	ITCH	289:292	Mutation rewiring degron network	0.1111
p.E281K	NCI-H2342	lung	COSMIC	PPNY	ITCH	289:292	Mutation rewiring degron network	0.1111
p.Q293L	ACH-000455	Brain Cancer	CCLE	PPNY	ITCH	289:292	Mutation rewiring degron network	0.3056
p.S300L	ACH-001415	Bladder Cancer	CCLE	PPNY	ITCH	289:292	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc