DegronMD - Q71SY5(MED25)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L265M	TCGA-AP-A059	UCEC	TCGA	PPQY	ITCH	269:272	Mutation rewiring degron network	0.2222
p.L265M	DO41361	UCEC	ICGC	PPQY	ITCH	269:272	Mutation rewiring degron network	0.2222
p.P275H	TCGA-AP-A1DK	UCEC	TCGA	PPQY	ITCH	269:272	Mutation rewiring degron network	0.25
p.G276E	TCGA-D3-A8GL	SKCM	TCGA	PPQY	ITCH	269:272	Mutation rewiring degron network	0.2222
p.P269L	TCGA-EE-A2GD	SKCM	TCGA	PPQY	ITCH	269:272	Mutation altering degron motif	0.7582
p.P269L	DO37603	SKCM	ICGC	PPQY	ITCH	269:272	Mutation altering degron motif	0.7582
p.P267S	DO233261	GACA	ICGC	PPQY	ITCH	269:272	Mutation rewiring degron network	0.2778
p.L273P	DO17781	KIRC	ICGC	PPQY	ITCH	269:272	Mutation rewiring degron network	0.3056
p.P270L	DO232532	PBCA	ICGC	PPQY	ITCH	269:272	Mutation altering degron motif	0.7582
p.P270S	DO37723	SKCM	ICGC	PPQY	ITCH	269:272	Mutation altering degron motif	0.6752
p.G278S	DO51761	STAD	ICGC	PPQY	ITCH	269:272	Mutation rewiring degron network	0.1667
p.A282V	DO41626	UCEC	ICGC	PPQY	ITCH	269:272	Mutation rewiring degron network	0.0556
p.R275H	DO42608	UCEC	ICGC	PPQY	ITCH	269:272	Mutation rewiring degron network	0.25
p.P275S	SIDM00185	Melanoma	GDSC	PPQY	ITCH	269:272	Mutation rewiring degron network	0.25
p.P275S	ACH-002152	Skin Cancer	CCLE	PPQY	ITCH	269:272	Mutation rewiring degron network	0.25
p.P275S	LB2518-MEL	skin	COSMIC	PPQY	ITCH	269:272	Mutation rewiring degron network	0.25
p.V268I	SIDM01145	Gastric Carcinoma	GDSC	PPQY	ITCH	269:272	Mutation rewiring degron network	0.3056
p.V268I	SIDM00159	Biliary Tract Carcinoma	GDSC	PPQY	ITCH	269:272	Mutation rewiring degron network	0.3056
p.V268I	ACH-000182	Bile Duct Cancer	CCLE	PPQY	ITCH	269:272	Mutation rewiring degron network	0.3056
p.V268I	ACH-000581	Gastric Cancer	CCLE	PPQY	ITCH	269:272	Mutation rewiring degron network	0.3056
p.V268I	NCI-SNU-16	stomach	COSMIC	PPQY	ITCH	269:272	Mutation rewiring degron network	0.3056
p.L278V	SIDM00081	Melanoma	GDSC	PPQY	ITCH	269:272	Mutation rewiring degron network	0.1667
p.L278V	ACH-000615	Skin Cancer	CCLE	PPQY	ITCH	269:272	Mutation rewiring degron network	0.1667
p.L278V	SK-MEL-28	skin	COSMIC	PPQY	ITCH	269:272	Mutation rewiring degron network	0.1667
p.A280E	SIDM00490	Glioma	GDSC	PPQY	ITCH	269:272	Mutation rewiring degron network	0.1111
p.A280E	ACH-001016	Brain Cancer	CCLE	PPQY	ITCH	269:272	Mutation rewiring degron network	0.1111
p.A280E	Becker	central nervous system	COSMIC	PPQY	ITCH	269:272	Mutation rewiring degron network	0.1111
p.G259C	DND-41	haematopoietic and lymphoid tissue	COSMIC	PPQY	ITCH	269:272	Mutation rewiring degron network	0.0556
p.L267V	SK-MEL-5	skin	COSMIC	PPQY	ITCH	269:272	Mutation rewiring degron network	0.2778

Kaplan plot for MED25 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MED25

UniProt ID: Q71SY5

Entrez ID: 81857

Protein name: Mediator of RNA polymerase II transcription subunit 25 (Activator interaction domain-containing protein 1) (Activator-recruited cofactor 92 kDa component) (ARC92) (Mediator complex subunit 25) (p78)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MED25 in