DegronMD - Q7Z2Y5(NRK)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1120D	TCGA-49-AAQV	LUAD	TCGA	DSGAAPS	DEG_SCF_TRCP1_1	1117:1123	Mutation altering degron motif	0.7198
p.G1120D	TCGA-B5-A1MX	UCEC	TCGA	DSGAAPS	DEG_SCF_TRCP1_1	1117:1123	Mutation altering degron motif	0.7198
p.G1120D	DO218916	LUAD	ICGC	DSGAAPS	DEG_SCF_TRCP1_1	1117:1123	Mutation altering degron motif	0.7198
p.G1120D	DO41999	UCEC	ICGC	DSGAAPS	DEG_SCF_TRCP1_1	1117:1123	Mutation altering degron motif	0.7198
p.A1116V	TCGA-BR-6852	STAD	TCGA	DSGAAPS	DEG_SCF_TRCP1_1	1117:1123	Mutation rewiring degron network	0.3056
p.A1116V	DO38202	STAD	ICGC	DSGAAPS	DEG_SCF_TRCP1_1	1117:1123	Mutation rewiring degron network	0.3056
p.S1119P	TCGA-BR-8589	STAD	TCGA	DSGAAPS	DEG_SCF_TRCP1_1	1117:1123	Mutation altering degron motif	0.6752
p.S1119P	DO47813	STAD	ICGC	DSGAAPS	DEG_SCF_TRCP1_1	1117:1123	Mutation altering degron motif	0.6752
p.E1112K	TCGA-D3-A8GI	SKCM	TCGA	DSGAAPS	DEG_SCF_TRCP1_1	1117:1123	Mutation rewiring degron network	0.1944
p.E1112K	DO222395	MELA	ICGC	DSGAAPS	DEG_SCF_TRCP1_1	1117:1123	Mutation rewiring degron network	0.1944
p.E1112K	DO50284	SKCM	ICGC	DSGAAPS	DEG_SCF_TRCP1_1	1117:1123	Mutation rewiring degron network	0.1944
p.N1111T	TCGA-RD-A7BT	STAD	TCGA	DSGAAPS	DEG_SCF_TRCP1_1	1117:1123	Mutation rewiring degron network	0.1667
p.N1111T	DO50131	STAD	ICGC	DSGAAPS	DEG_SCF_TRCP1_1	1117:1123	Mutation rewiring degron network	0.1667
p.S1119A	TCGA-VQ-A8PK	STAD	TCGA	DSGAAPS	DEG_SCF_TRCP1_1	1117:1123	Mutation altering degron motif	0.7588
p.S1119A	DO51771	STAD	ICGC	DSGAAPS	DEG_SCF_TRCP1_1	1117:1123	Mutation altering degron motif	0.7588
p.A1125V	DO233855	GACA	ICGC	DSGAAPS	DEG_SCF_TRCP1_1	1117:1123	Mutation rewiring degron network	0.2778
p.P1123S	DO222396	MELA	ICGC	DSGAAPS	DEG_SCF_TRCP1_1	1117:1123	Mutation altering degron motif	0.6752
p.P1126L	DO222662	MELA	ICGC	DSGAAPS	DEG_SCF_TRCP1_1	1117:1123	Mutation rewiring degron network	0.25
p.N1131S	SIDM00663	Melanoma	GDSC	DSGAAPS	DEG_SCF_TRCP1_1	1117:1123	Mutation rewiring degron network	0.1111
p.N1131S	SIDM00072	Non-Cancerous	GDSC	DSGAAPS	DEG_SCF_TRCP1_1	1117:1123	Mutation rewiring degron network	0.1111
p.N1131S	SIDM00130	Pancreatic Carcinoma	GDSC	DSGAAPS	DEG_SCF_TRCP1_1	1117:1123	Mutation rewiring degron network	0.1111
p.N1131S	SIDM01768	Melanoma	GDSC	DSGAAPS	DEG_SCF_TRCP1_1	1117:1123	Mutation rewiring degron network	0.1111
p.S1123P	SIDM00433	T-Lymphoblastic Leukemia	GDSC	DSGAAPS	DEG_SCF_TRCP1_1	1117:1123	Mutation altering degron motif	0.6752
p.S1123P	ACH-000795	Leukemia	CCLE	DSGAAPS	DEG_SCF_TRCP1_1	1117:1123	Mutation altering degron motif	0.6752
p.A1112T	ACH-000938	Leukemia	CCLE	DSGAAPS	DEG_SCF_TRCP1_1	1117:1123	Mutation rewiring degron network	0.1944
p.K1132E	ACH-001719	Ovarian Cancer	CCLE	DSGAAPS	DEG_SCF_TRCP1_1	1117:1123	Mutation substituting flanking lysine	0.1944

Kaplan plot for NRK in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NRK

UniProt ID: Q7Z2Y5

Entrez ID: 203447

Protein name: Nik-related protein kinase (EC 2.7.11.1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NRK in