DegronMD - Q7Z698(SPRED2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T226K	TCGA-AB-2806	LAML	TCGA	DYR	CBL_MET	230:232	Mutation rewiring degron network	0.2222
p.T226K	DO21283	LAML	ICGC	DYR	CBL_MET	230:232	Mutation rewiring degron network	0.2222
p.G227E	TCGA-B2-5641	KIRC	TCGA	DYR	CBL_MET	230:232	Mutation rewiring degron network	0.25
p.G227E	DO19603	KIRC	ICGC	DYR	CBL_MET	230:232	Mutation rewiring degron network	0.25
p.T226M	TCGA-EO-A22U	UCEC	TCGA	DYR	CBL_MET	230:232	Mutation rewiring degron network	0.2222
p.T226M	TCGA-F4-6856	COAD	TCGA	DYR	CBL_MET	230:232	Mutation rewiring degron network	0.2222
p.E229G	TCGA-FR-A8YC	SKCM	TCGA	DYR	CBL_MET	230:232	Mutation rewiring degron network	0.3056
p.E229G	DO50301	SKCM	ICGC	DYR	CBL_MET	230:232	Mutation rewiring degron network	0.3056
p.T223M	DO9114	COAD	ICGC	DYR	CBL_MET	230:232	Mutation rewiring degron network	0.1389
p.T223M	DO43755	UCEC	ICGC	DYR	CBL_MET	230:232	Mutation rewiring degron network	0.1389
p.E229D	DO222492	COCA	ICGC	DYR	CBL_MET	230:232	Mutation rewiring degron network	0.3056
p.D242E	DO228976	LICA	ICGC	DYR	CBL_MET	230:232	Mutation rewiring degron network	0.0556
p.P240S	DO232028	LICA	ICGC	DYR	CBL_MET	230:232	Mutation rewiring degron network	0.1111
p.P241Q	DO229019	LICA	ICGC	DYR	CBL_MET	230:232	Mutation rewiring degron network	0.0833
p.E221K	SIDM00007	Other Solid Cancers	GDSC	DYR	CBL_MET	230:232	Mutation rewiring degron network	0.0833
p.E221K	MCC13	skin	COSMIC	DYR	CBL_MET	230:232	Mutation rewiring degron network	0.0833
p.R220Q	SIDM00007	Other Solid Cancers	GDSC	DYR	CBL_MET	230:232	Mutation rewiring degron network	0.0556
p.R220Q	SIDM00217	Colorectal Carcinoma	GDSC	DYR	CBL_MET	230:232	Mutation rewiring degron network	0.0556
p.R220Q	MCC13	skin	COSMIC	DYR	CBL_MET	230:232	Mutation rewiring degron network	0.0556
p.A234V	SIDM01609	Endometrial Carcinoma	GDSC	DYR	CBL_MET	230:232	Mutation rewiring degron network	0.2778
p.P240L	ACH-000877	Lymphoma	CCLE	DYR	CBL_MET	230:232	Mutation rewiring degron network	0.1111
p.P240L	ACH-001064	Lymphoma	CCLE	DYR	CBL_MET	230:232	Mutation rewiring degron network	0.1111
p.P240L	EB2	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	230:232	Mutation rewiring degron network	0.1111
p.A231V	ACH-000972	Endometrial/Uterine Cancer	CCLE	DYR	CBL_MET	230:232	Mutation altering degron motif	0.6936

Kaplan plot for SPRED2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPRED2

UniProt ID: Q7Z698

Entrez ID: 200734

Protein name: Sprouty-related, EVH1 domain-containing protein 2 (Spred-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPRED2 in