DegronMD - Q7Z7G1(CLNK)

CLNK

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N232K	TCGA-75-7027	LUAD	TCGA	AISSS	DEG_SPOP_SBC_1	241:245	Mutation rewiring degron network	0.0833
p.N232K	DO24811	LUAD	ICGC	AISSS	DEG_SPOP_SBC_1	241:245	Mutation rewiring degron network	0.0833
p.T248M	TCGA-BH-A0B9	BRCA	TCGA	AISSS	DEG_SPOP_SBC_1	241:245	Mutation rewiring degron network	0.25
p.T248M	DO1459	BRCA	ICGC	AISSS	DEG_SPOP_SBC_1	241:245	Mutation rewiring degron network	0.25
p.L240I	DO229026	LICA	ICGC	AISSS	DEG_SPOP_SBC_1	241:245	Mutation rewiring degron network	0.3056
p.Q233K	DO229037	LICA	ICGC	AISSS	DEG_SPOP_SBC_1	241:245	Mutation rewiring degron network	0.1111
p.A241V	SIDM00663	Melanoma	GDSC	AISSS	DEG_SPOP_SBC_1	241:245	Mutation altering degron motif	0.5825
p.A241V	ACH-000814	Skin Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	241:245	Mutation altering degron motif	0.5825
p.A241V	Hs939-T	skin	COSMIC	AISSS	DEG_SPOP_SBC_1	241:245	Mutation altering degron motif	0.5825
p.S245Y	SIDM00193	Colorectal Carcinoma	GDSC	AISSS	DEG_SPOP_SBC_1	241:245	Mutation altering degron motif	0.712
p.S245Y	ACH-000991	Colon/Colorectal Cancer	CCLE	AISSS	DEG_SPOP_SBC_1	241:245	Mutation altering degron motif	0.712
p.S245Y	SNU-81	large intestine	COSMIC	AISSS	DEG_SPOP_SBC_1	241:245	Mutation altering degron motif	0.712
p.T235S	SKN-3	upper aerodigestive tract	COSMIC	AISSS	DEG_SPOP_SBC_1	241:245	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc